Table 9 Differentially regulated genes between purified macrophages from Scnn1b- Tg and WT mice
PND 0 | PND 3 | PND 10 | PND 42 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Name | Fold- Change | FDR p-value | Gene Name | Fold-Change | FDR p-value | Gene Name | Fold- Change | FDR p-value | Gene Name | Fold- Change | FDR p-value |
UP-REGULATED | |||||||||||
Acta1 | 43.4 | 9.12E-16 | Lcn2 | 42.6 | 4.11E-05 | Inhba | 25.8 | 1.04E-05 | Ear11 | 137.8 | 4.70E-06 |
Tnnc2 | 37.9 | 4.27E-15 | Stfa3 | 35.2 | 1.70E-05 | Mmp14 | 22.3 | 1.14E-06 | Fstl1 | 85.4 | 6.63E-12 |
Csn1s2a | 32.6 | 2.11E-06 | Gm5416 | 32.0 | 4.46E-05 | Irg1 | 17.1 | 9.85E-05 | Rbp4 | 70.5 | 3.57E-09 |
Tg | 25.9 | 3.53E-03 | Thbs1 | 27.3 | 6.67E-06 | Npy | 15.3 | 4.18E-05 | Fbp1 | 67.1 | 2.23E-05 |
Csn2 | 23.4 | 5.58E-05 | Stfa2 | 26.4 | 9.55E-05 | H2-M2 | 14.0 | 1.58E-09 | Mfge8 | 52.0 | 1.38E-11 |
Mylpf | 22.7 | 1.19E-07 | Chi3l1 | 20.6 | 8.07E-06 | Slc11a1 | 12.8 | 5.51E-06 | Awat1 | 51.9 | 3.74E-08 |
Scnn1b | 21.5 | 2.01E-03 | Saa3 | 20.2 | 2.00E-04 | Clec4e | 12.3 | 5.88E-06 | Arg1 | 42.7 | 1.17E-05 |
Wap | 19.5 | 7.79E-04 | Inhba | 20.1 | 1.74E-05 | Cxcl2 | 11.9 | 2.64E-06 | Inhba | 36.8 | 5.26E-07 |
Slc4a1 | 17.8 | 8.38E-03 | Cxcl1 | 15.8 | 2.63E-06 | Pmp22 | 11.0 | 1.20E-03 | Mmp12 | 33.9 | 7.64E-09 |
Glycam1 | 17.7 | 3.44E-04 | Stfa2l1 | 15.8 | 2.75E-03 | Ass1 | 10.9 | 2.25E-05 | Retnla | 33.8 | 3.12E-04 |
Car3 | 16.1 | 1.90E-03 | Prok2 | 14.3 | 4.83E-11 | Hp | 10.3 | 7.72E-06 | Ppap2b | 27.8 | 3.32E-12 |
Rsad2 | 16.0 | 2.29E-03 | Plbd1 | 14.0 | 4.65E-05 | Mfge8 | 10.0 | 1.22E-06 | H2-M2 | 25.0 | 6.63E-12 |
Csn1s1 | 15.9 | 1.70E-03 | Irg1 | 13.9 | 1.09E-04 | Cxcl3 | 9.7 | 2.62E-04 | Ccl24 | 24.2 | 1.07E-03 |
Tnnt3 | 15.2 | 1.58E-08 | Gm10872* | 13.9 | 7.19E-04 | Cxcl16 | 9.2 | 2.64E-06 | Bex1 | 18.9 | 2.04E-08 |
Gypa | 14.0 | 9.23E-03 | Cxcl3 | 13.6 | 2.25E-05 | Pla2g7 | 8.4 | 3.15E-04 | AA467197 | 17.4 | 2.17E-07 |
DOWN-REGULATED | |||||||||||
Gm10473 | -3.8 | 5.41E-03 | Coro6 | -6.1 | 4.47E-04 | Cidec | -2.7 | 1.07E-02 | Epcam | -5.2 | 4.79E-06 |
Gm24049* | -3.6 | 2.14E-02 | Hpgd | -5.1 | 4.44E-04 | Rab44 | -2.7 | 4.02E-04 | Gal | -5.1 | 6.71E-04 |
6720489N17Rik | -3.3 | 2.23E-02 | Fabp1 | -5.1 | 3.16E-04 | G0s2 | -2.6 | 1.33E-02 | Tnfsf13b | -4.8 | 6.04E-11 |
Lilra5 | -2.9 | 5.01E-04 | Flt1 | -3.6 | 8.97E-06 | Fam212a | -2.6 | 4.99E-03 | Dnahc11 | -4.5 | 2.76E-08 |
1600002K03Rik | -2.9 | 3.39E-02 | Kazald1 | -3.4 | 2.10E-03 | Gm5936 | -2.5 | 2.25E-02 | Kazald1 | -4.0 | 3.85E-04 |
Snora74a* | -2.8 | 4.99E-02 | Gpr34 | -2.9 | 6.50E-04 | Prr5l | -2.5 | 3.11E-02 | Nt5e | -4.0 | 5.80E-05 |
Snora73b* | -2.8 | 1.02E-02 | Slc6a4 | -2.9 | 3.94E-04 | Tmem150b | -2.4 | 9.43E-03 | Cpne5 | -3.9 | 4.10E-04 |
Gdf15 | -2.7 | 3.36E-03 | Gm1966 | -2.9 | 4.65E-05 | Csf3r | -2.4 | 2.37E-02 | Slc9a2 | -3.8 | 1.03E-05 |
Vgf | -2.7 | 3.30E-02 | Fam212a | -2.8 | 7.44E-04 | Cd2 | -2.4 | 4.82E-03 | Fam212a | -3.7 | 2.91E-05 |
2010005H15Rik | -2.7 | 3.73E-02 | Cd2 | -2.8 | 3.54E-04 | Klk8 | -2.4 | 1.20E-02 | Egfem1 | -3.7 | 9.82E-05 |
Aqp11 | -2.7 | 9.12E-03 | Klk8 | -2.8 | 9.32E-04 | Kcnh4 | -2.3 | 1.19E-02 | Gpr141 | -3.7 | 2.18E-03 |
P2ry13 | -2.6 | 7.04E-03 | Gm11545 | -2.8 | 1.37E-02 | Sec14l2 | -2.2 | 7.39E-03 | Itgad | -3.5 | 1.23E-05 |
F630111L10Rik* | -2.6 | 1.26E-02 | Rnase6 | -2.8 | 1.17E-02 | Gm12258 | -2.2 | 2.18E-02 | Iqgap2 | -3.4 | 5.72E-06 |
Ch25h | -2.6 | 2.26E-02 | Trp53i11 | -2.8 | 2.74E-02 | Gsg2 | -2.1 | 4.20E-03 | Pnpla5 | -3.3 | 6.36E-06 |
Krt6a | -2.6 | 3.37E-04 | Cidec | -2.7 | 6.13E-03 | Arhgef39 | -2.0 | 1.36E-02 | Grap2 | -3.3 | 7.52E-04 |