Figure 3

Functional analysis of differentially expressed (DE) genes. (A) Hierarchically clustered heat map for the expression profile of DE genes (reflecting log-2 transformed expression fold changes relative to the control) that are either only up-regulated (left) or down-regulated (middle), as well as the remaining DE genes, whose expression changes in an inconsistently manner (right). (B) Plot of gene ontology (GO) terms (from the third level of biological process category) for the DE genes falling into either the consistently up- (red) or down- (green) regulated categories. Enrichment was measured by comparing the number of genes from each DE category to the total number of genes for that GO term and using Fisher’s exact test, significance is indicated for resulting p-values below 0.01 or between 0.01 and 0.05 by double or single asterisks, respectively.