Table 2 Summary of Gene Ontology (GO) Analysis of differentially expressed gene lists
Cluster | Biological process of cluster | # genes | # Enriched subcategories | Example Drosophila homologs |
|---|---|---|---|---|
Brain dominance-associated | ||||
C1 | Compound eye development, photoreceptor cell differentiation | 4 | 7/0 | COP9 complex homolog subunit 4, microtubule star, rasputin, scabrous |
C2 | Cytoskeletal organization, actin filament organization | 5 | 1/0 | Paramyosin, Transitional endoplasmic reticulum, upheld |
C3 | Phagocytosis, vesicle mediated transport | 4 | 0/0 | Beadex, alpha-coatomer protein |
C4 | Reproduction, oogenesis | 6 | 0/0 | COP9 complex homolog subunit , Glutamate dehydrogenase, quick-to-court |
C5 | Nucleotide, ATP binding | 8 | 0/0 | Hexokinase A, polyA-binding protein, rasputin |
C6 | Zinc, ion, metal binding | 7 | 0/0 | Nucleosome remodeling factor - 38kD, Sorbitol dehydrogenase-2, upheld |
Brain caste-associated | ||||
C1 | Oxidation reduction | 12 | 8/0 | Ecdysone-induced protein 28/29kD, Glutathione peroxidase, Malate dehydrogenase, Sorbitol dehydrogenase-2 |
C2 | Aging, determination of adult life span | 4 | 0/0 | Autophagy-specific gene 7, Excitatory amino acid transporter 1 |
C3 | Cell cycle process, microtubule-based process, cytoskeletal organization | 8 | 0/0 | Eukaryotic initiation factor 4E, Helicase at 25E, Ribosomal protein L3, microtubule star, stubarista |
C4 | Regulation of RNA metabolism | 8 | 0/0 | Brahma associated protein 60kD, X box binding protein-1 |
C5 | RNA splicing, binding, processing | 7 | 0/0 | Polyadenylate-binding protein 2, U2 small nuclear riboprotein auxiliary factor 50, hiiragi |
C6 | Metamorphosis, morphogenesis, cell death | 5 | 0/0 | Autophagy-specific gene 7, mastermind, scabrous |
C7 | Synaptic transmission | 5 | 0/0 | Glutamic acid decarboxylase , longitudinals lacking |
Ovary dominance-associated | ||||
C1 | Protein folding | 18 | 0/0 | Cyclophilin 1, DnaJ-like-2, Heat shock protein cognate 4, T-complex Chaperonin 5 |
C2 | Proteolysis | 52 | 1/0 | Serine protease inhibitor 4, amontillado, supernumerary limbs, Proteasome 29kD subunit |
C3 | Mitotic spindle organization | 36 | 7/0 | Replication Protein A 70, Ribosomal protein S4, short spindle 4, Dynein heavy chain 64C |
C4 | Oxidative phosphorylation | 16 | 0/0 | ATP synthase-beta, V-type proton ATPase subunit d 1, NADH:ubiquinone reductase 75kD subunit precursor |
C5 | Regulation of cell projection, morphogenesis, differentiation | 14 | 1/0 | Calcium/calmodulin-dependent protein kinase II, twinstar, short stop, capping protein alpha |
C6 | Carboxylic and amino acid catabolic process | 6 | 0/0 | Glutamate dehydrogenase, Probable maleylacetoacetate isomerase 2, sluggish A |
C7 | Lipoprotein metabolism | 4 | 0/0 | N-myristoyl transferase, Putative GPI-anchor transamidase, Rab escort protein |
Ovary caste-associated | ||||
C1 | Cytoskeletal organization, mitotic spindle organization | 94 | 11/0 | Brahma associated protein 55kD, Dynamitin, Kinesin heavy chain, notch |
C2 | Protein folding | 29 | 1/1 | Calreticulin, Cyclophilin , Probable prefoldin subunit 4, Protein disulfide isomerase |
C3 | Translation | 61 | 3/0 | Elongation factor 1-gamma, Transcription factor IIB, Ribosomal protein S17 |
C4 | Cofactor metabolic/biosynthetic process | 29 | 3/0 | Coenzyme Q biosynthesis protein 2, maroon-like, Succinate dehydrogenase B, Glutamate dehydrogenase |
C5 | Generation of precursor metabolites and energy, oxidative phosphorylation | 45 | 5/0 | Aconitase, Aldolase, Cytochrome c oxidase subunit Va, Pyruvate kinase |
C6 | Proteolysis | 83 | 8/0 | Diphenol oxidase A2, Insulin degrading metalloproteinase, Ubiquitin carrier protein, fizzy |
C7 | Glucose and hexose metabolism | 23 | 6/0 | Hexokinase A, Phosphoenolpyruvate carboxykinase, Phosphofructokinase |