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Table 2 Relatively enriched motifs in tamoxifen-treated vs. untreated MCF10A-ER-Src cells

From: Differential motif enrichment analysis of paired ChIP-seq experiments

FOS

4 hr

 

12 hr

 

36 hr

 

Motif

E-value

Motif

E-value

Motif

E-value

STAT1

5.7e-22

STAT1

1.6e-24

STAT1

1.5e-17

Stat3

7.2e-18

Stat3

3.3e-21

Stat3

1.4e-05

FLI1_full

1.3e-08

FEV

1.1e-14

ATF4_DBD

2.2e-05

FEV_DBD

1.9e-08

ETS1_DBD

1.1e-13

NFIL3_DBD

7.4e-05

ETV4_DBD

3.1e-08

ELK3_DBD

1.3e-13

HLF_full

0.00015

ELK1_DBD

5.7e-08

FLI1_full

1.4e-13

ETV1_DBD

0.00032

FLI1_DBD

5.8e-08

ERG_DBD

1.6e-13

ETV4_DBD

0.00037

ERG_DBD

8.1e-08

ERG_full

1.6e-13

HLF

0.00048

ELK3_DBD

8.8e-08

ELK1_DBD

2.2e-13

ELK3_DBD

0.00063

ETS1_full

1.1e-07

RELA

3.3e-13

ETV6_full_2

0.0011

MYC

 

STAT3

4 hr

 

12 hr

 

36 hr

 

Motif

E-value

Motif

E-value

Motif

E-value

Fos

5.7e-17

Fos

1.8e-42

Fos

1.7e-32

AP1

3.4e-16

AP1

9.7e-33

AP1

2.2e-22

STAT1

1.1e-08

JDP2_DBD

1.5e-21

JDP2_full

3.4e-20

Stat3

0.0027

JDP2_full

1.1e-20

JDP2_DBD

1.2e-19

RELA

0.0085

Jdp2_DBD

6.4e-17

Jdp2_DBD

5.3e-18

NF-kappaB

0.0088

NFE2_DBD

3e-14

NFE2_DBD

1.2e-10

NFE2L1::MafG

0.065

NFE2L1::MafG

6.8e-09

NFE2L1::MafG

8e-09

CEBPA

0.11

NFE2L2

9.7e-05

MEOX2_DBD

0.0077

FEV

0.28

MAFF_DBD

0.27

NFE2L2

0.0078

REL

0.49

Pax2

0.3

MEOX1_full

0.097

  1. The table shows the ten most differentially enriched motifs in ChIP-seq peaks for the given ChIP-ed TF (top lines) in MCF10A-ER-Src cells treated with tamoxifen for the given time (second lines) compared with untreated cells. The name of the JASPAR or Jolma et al.[3] motif and its Fisher E-value as computed by CentriMo are given and each column in the table is sorted by E-value. Significant (0.05) E-values are shown in bold font. All enriched motifs have odds ratios at least 1.09.