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Table 3 Motifs that are not enriched in untreated MCF10A-ER-Src cells but that are enriched in tamoxifen-treated cells

From: Differential motif enrichment analysis of paired ChIP-seq experiments

FOS
4 hr   12 hr   36 hr  
Motif E-value Motif E-value Motif E-value
STAT1 5.7e-22 STAT1 1.6e-24 STAT1 1.5e-17
SPI1 0.003 REL 2.7e-09 BSX_DBD 0.8
CTCF 3.1 NF-kappaB 7.4e-09 UNCX_DBD 7.3
NFKB2_DBD 6.7 NFKB2_DBD 2.2e-05 PDX1_DBD_2 8.8
SPIB 27 NFKB1 8.5e-05 Dbp_DBD 17
RXR::RAR_DR5 159 ETS1 0.00057 NKX6-2_full 28
SP1 159 CTCF 0.0065 HNF1A_full 45
INSM1 177 SPIB 0.8 POU6F2_full 48
NFKB1 239 Spic_DBD 177 Dlx2_DBD 50
RARG_full_3 557 SPI1 212 Lhx8_DBD_2 50
MYC   STAT3
4 hr   12 hr   36 hr  
Motif E-value Motif E-value Motif E-value
STAT1 1.1e-08 AP1 9.7e-33 MEOX2_DBD 0.0077
NF-kappaB 0.0088 Hoxa2_DBD 42 DLX5_FL 0.11
NFKB1 1.2 SPIB_DBD 53 En2_DBD 0.13
NFKB1_DBD 9.7 POU1F1_DBD 239 POU1F1_DBD 0.22
NFKB2_DBD 9.7 VAX2_DBD 265 Meox2_DBD 0.57
EN1_full_2 12 En2_DBD 309 Hoxa2_DBD 0.7
NR2E1_full 15 MZF1_1-4 398 VAX1_DBD 1.6
TEAD1_full 23 ZIC3_full 415 EMX2_DBD 2.4
MEOX2_DBD 33 Nkx6-1_DBD 424 HOXB5_DBD 2.5
MZF1_1-4 36 HMBOX1_DBD 442 EVX2_DBD 4.5
  1. The table shows the most differentially enriched motifs in ChIP-seq peaks in tamoxifen treated cells where the motif is not significantly enriched (E-value 1) in the untreated MCF10A-ER-Src cells. The first two lines show the ChIP-ed TF and the tamoxifen treatment time, respectively. The name of the JASPAR or Jolma et al.[3] motif and the significance of its differential enrichment (Fisher E-value) as computed by CentriMo are given and each column in the table is sorted by E-value. Significant (0.05) E-values are shown in bold font.