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Figure 4 | BMC Genomics

Figure 4

From: Combinatorial epigenetic patterns as quantitative predictors of chromatin biology

Figure 4

Basis patterns at promoters and their role in Pol2 recruitment. (A) Basis patterns associated with promoter-regions in ES cells. Graphical representation of the H factor matrix of the "absolute" algorithm. Rows correspond to basis patterns (codes), columns to epigenetic marks. The height of each bar is equal to the loading of a mark on a code. The codes are sparse i.e. most values are very close to zero. Most marks have significant loading (by visual inspection) in one or two codes with the exception of H4K20me1. (B) Codes in the Pol2-expression plane. Each dot represents a promoter of a protein-coding gene. The Y-axis represents normalized levels of Pol2 binding; the X-axis is the normalized expression level the associated gene. Each genes was assigned a label of the code with the highest weight. Genes assigned to codes 2 and 6 are shown.

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