Figure 4

Competition experiments between wild type D39 (A), WCH16 (B), WCH43 (C) and their codY^indisogenic counterparts in the nasopharynx, lungs, blood and brain (n = 16) 36 h post-i.n. infection with equal numbers (approx. 2.5 × 10⁶ CFU) each of wild type and isogenic derivative. Datum points are the ratio of codY^ind bacteria to wild type for each animal. The horizontal broken line represents a 1:1 ratio. The horizontal solid line denotes the geometric mean ratio for each comparison (NS = Not Significant; *** P < 0.001; **** P < 0.0001; one sample t-test, two-tailed).