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Table 2 GxE variance contribution of erythrocyte n-3 polyunsaturated fatty acids to four diabetes-related traits in GOLDN 1

From: Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits

Trait E factor P-nominal (gxe)2 Vg SE V(gxe) SE h2(g), % (95% CI) SE h2(gxe), % (95% CI) SE h2(g + gxe), % (95% CI)
HOMA-IR DPA 0.034 0.0007 0.0005 0.0015 0.0008 12.8 (0, 30.6) 9.1 26.5 (0, 55.7) 14.9 39.4 (15.9, 62.9)
Fasting insulin DPA 0.042 0.0002 0.0002 0.0006 0.0004 8.6 (0, 25.8) 8.8 24.3 (0, 53.1) 14.7 32.9 (9.87, 55.9)
Fasting glucose AA/ (EPA + DHA) 0.023 0.4518 0.3076 0.9295 0.4979 13.1 (0, 30.3) 8.8 27.0 (0, 55.0) 14.3 40.2 (17.6, 62.8)
Adiponectin AA/ EPA 0.058 0.0200 0.0044 0.0072 0.0052 44.4 (27.3, 61.5) 8.7 16.0 (0, 38.3) 11.4 60.4 (40.7, 80.1)
  1. 1HOMA-IR, HOMA-Insulin Resistance; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; ALA, alpha -linolenic acid; AA, arachidonic acid;Vg, additive genetic variance; V(gxe), variance contributed by GxE interaction; SE, standard error; h2 (g), additive genetic heritability; h2 (gxe), heritability explained by GxE interaction; h2 (g + gxe), total heritability. GxE heritability was calculated as the GxE variance divided by the total phenotypic variance. Only the nominal significant E factors were listed in this table, results of other E factors were listed in the Additional files 1 and 2.
  2. 2P-value (gxe) of GxE interaction was adjusted for age, sex, body mass index, study center, energy intake, kinship, and population structure.