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Table 3 Estimation of GxE variance for paired environmental factors on four diabetes-related traits in GOLDN 1

From: Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits

Trait E factor h2(g) SE h2(gxe) SE P-nominal2
HOMA-IR DPA 0.100 0.099 0.264 0.149 0.034
n-3 PUFA    0.096 0.135 0.225
DPA 0.067 0.103 0.291 0.149 0.023
n-6 PUFA    0.194 0.138 0.069
DPA 0.124 0.099 0.250 0.149 0.044
DHA    0.052 0.134 0.342
Fasting insulin DPA 0.050 0.097 0.242 0.146 0.041
n-3 PUFA    0.141 0.144 0.161
DPA 0.025 0.099 0.261 0.146 0.032
n-6 PUFA    0.243 0.144 0.039
DPA 0.076 0.097 0.228 0.146 0.053
DHA    0.066 0.139 0.312
Fasting glucose AA/ (DHA + EPA) 0.127 0.091 0.264 0.160 0.043
n-6/ n-3 PUFA    0.018 0.150 0.450
AA/ (DHA + EPA) 0.112 0.090 0.279 0.163 0.032
DHA + EPA    0.000 0.150 0.500
Adiponectin AA/ EPA 0.447 0.088 0.096 0.151 0.265
EPA    0.078 0.157 0.318
AA/ EPA 0.419 0.096 0.159 0.115 0.061
AA/ DHA    0.094 0.122 0.210
  1. 1For each trait, one significant E factor (significant GxE variance contributor) was simultaneously paired with another E factor into the model, and corresponding GxE variance for either E factor was estimated in the model. GxE heritability was calculated as the GxE variance divided by the total phenotypic variance. PUFA, polyunsaturated fatty acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; ALA, alpha-linolenic acid; AA, arachidonic acid; SE, standard error; h2(g), heritability of additive genetic variance; h2 (gxe), heritability of GxE interaction.
  2. 2P-values were adjusted for age, sex, body mass index, study center, energy intake, kinship, and population structure.