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Table 3 Estimation of GxE variance for paired environmental factors on four diabetes-related traits in GOLDN 1

From: Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits

Trait

E factor

h2(g)

SE

h2(gxe)

SE

P-nominal2

HOMA-IR

DPA

0.100

0.099

0.264

0.149

0.034

n-3 PUFA

  

0.096

0.135

0.225

DPA

0.067

0.103

0.291

0.149

0.023

n-6 PUFA

  

0.194

0.138

0.069

DPA

0.124

0.099

0.250

0.149

0.044

DHA

  

0.052

0.134

0.342

Fasting insulin

DPA

0.050

0.097

0.242

0.146

0.041

n-3 PUFA

  

0.141

0.144

0.161

DPA

0.025

0.099

0.261

0.146

0.032

n-6 PUFA

  

0.243

0.144

0.039

DPA

0.076

0.097

0.228

0.146

0.053

DHA

  

0.066

0.139

0.312

Fasting glucose

AA/ (DHA + EPA)

0.127

0.091

0.264

0.160

0.043

n-6/ n-3 PUFA

  

0.018

0.150

0.450

AA/ (DHA + EPA)

0.112

0.090

0.279

0.163

0.032

DHA + EPA

  

0.000

0.150

0.500

Adiponectin

AA/ EPA

0.447

0.088

0.096

0.151

0.265

EPA

  

0.078

0.157

0.318

AA/ EPA

0.419

0.096

0.159

0.115

0.061

AA/ DHA

  

0.094

0.122

0.210

  1. 1For each trait, one significant E factor (significant GxE variance contributor) was simultaneously paired with another E factor into the model, and corresponding GxE variance for either E factor was estimated in the model. GxE heritability was calculated as the GxE variance divided by the total phenotypic variance. PUFA, polyunsaturated fatty acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; ALA, alpha-linolenic acid; AA, arachidonic acid; SE, standard error; h2(g), heritability of additive genetic variance; h2 (gxe), heritability of GxE interaction.
  2. 2P-values were adjusted for age, sex, body mass index, study center, energy intake, kinship, and population structure.