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Table 5 Replication of GxE variance contribution of erythrocyte n-3 polyunsaturated fatty acids to diabetes-related traits in the BPRHS 1

From: Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits

Trait E factor P-nominal (gxe)2 Vg SE V(gxe) SE h2(g), % (95%CI) SE h2(gxe), % (95%CI) SE h2(g + gxe), % (95%CI)
HOMA-IR DPA 0.068 0.0150 0.0300 0.0446 0.0451 4.34 (0, 21.3) 8.66 12.9 (0, 38.4) 13.0 17.1 (0, 38.3)
ALA 0.500 0.0350 0.0350 0 0.019 10.0 (0, 29.2) 9.8 0 (0, 10.5) 5.35 10.0 (0, 24.8)
Fasting insulin DPA 0.033 0.0034 0.0232 0.0531 0.0463 1.16 (0, 16.6) 7.89 18.0 (0, 48.6) 15.6 19.2 (0, 42.2)
ALA 0.500 0.0222 0.0251 0 0.0165 7.45 (0, 23.9) 8.40 0 (0, 10.8) 5.52 7.45 (0, 21.1)
Fasting glucose AA/ (EPA + DHA) 0.252 0.0016 0.0015 0.0004 0.0007 13.3 (0, 38.0) 12.6 3.09 (0, 15.1) 6.14 16.4 (0, 34.8)
ALA 0.500 0.0019 0.0017 0 0.0005 16.2 (0, 43.4) 13.9 0 (0, 9.07) 4.63 16.2 (0, 34.4)
  1. 1DPA, docosapentaenoic acid; ALA, alpha -linolenic acid; Vg, additive genetic variance; V(gxe), variance contributed by GxE interaction; SE, standard error; h2 (g), additive genetic heritability; h2 (gxe), heritability explained by GxE interaction; h2 (g + gxe), total heritability. GxE heritability was calculated as the GxE variance divided by the total phenotypic variance. ALA was served as a control.
  2. 2P-value (gxe) of GxE interaction was adjusted for age, sex, body mass index, energy intake and population structure.