Table 1 Selected differentially regulated genes of B. pseudomallei K96243 and σ ^E mutant under H ₂ O ₂ –induced oxidative stress

Oxidative stress responsive gene (OSR gene)

bpss0993

KatB

5.90

NS

bpss0492

AhpC

4.54

NS

bpsl2865

KatG

3.64

NS

bpss0238

Penicillin-binding protein

3.03

NS

bpss0281

4 Aminobutyrate aminotransferase

2.80

NS

bpss0711

Alanine racemase

2.25

NS

bpsl3142

BolA-like protein

1.94

NS

bpsl2285

Chaperone protein HscA

1.88

NS

bpsl0497

Periplasmic TonB protein

1.54

NS

bpsl2286

Co-chaperone HscB

1.43

NS

bpsl1787

ECF sigma factors

1.41

NS

bpsl0785

Peptidase

1.19

NS

bpsl0963

Putative permease protein

1.13

NS

bpsl2806

Capsular polysaccharide

1.07

NS

bpss0585

AraC family transcriptional regulator

1.07

NS

bpsl1527

Tex transcriptional factor

1.05

NS

bpsl0186

MreB

1.04

NS

bpsl3312

Putative glycosyltransferase

1.00

NS

σ ^E -dependent and OSR gene

bpss1837

Hypothetical protein

3.37

−1.84

bpss1839

Oxidative stress related rubrerythrin protein

3.36

−1.68

bpss1838

Ferredoxin

3.31

−1.79

bpsl2931

Eda (KHG/KDPG_aldolase)

3.26

−2.59

bpsl2932

Phosphogluconate dehydratase

3.17

−2.13

bpsl2605

TrxB

2.75

−1.18

bpsl1799

Putative fimbrial chaperone

2.70

−1.71

bpsl1800

Putative outer membrane usher protein precursor

2.59

−1.86

bpss1437

Lipoprotein

2.42

−2.27

bpss1251

N-carbamoyl-L-amino N-acid amidohydrolase

2.34

−1.01

bpss1434

Membrane-anchored cell surface protein

2.33

−3.52

bpsl3419

Putative GMC oxidoreductase

2.27

−1.22

bpss1252

Inner membrane transport protein

2.20

−1.11

bpsl2300

PdhB

2.19

−1.34

bpsl2301

PdhA

1.89

−1.68

T6SS-4

BPSS0175

1.89

−3.67

BPSS0176

1.77

−3.55

BPSS 0177

1.70

−3.78

BPSS 0178

1.99

−2.92

BPSS 0179

1.94

−2.56

BPSS 0180

1.70

−2.50

BPSS 0181

1.68

−2.16

BPSS0182

1.14

−1.50

BPSS0183

1.06

−1.09

BPSS0184

1.04

−1.22

bpsl2933

Putative regulatory protein

1.61

−1.29

bpsl1042

Putative lipoprotein

1.61

−1.43

bpsl1806

Subfamily M23B unassigned peptidase

1.57

−1.60

bpsl1983

Putative two component system histidine kinase

1.41

−1.00

bpss0796A

H-NS-like protein

1.41

−1.32

bpsl0609

Fis family regulatory protein

1.31

−3.20

bpsl0320

PfkB family carbohydrate kinase

1.31

−1.10

bpss0016

Phospholipase

1.23

−2.72

bpss0124

Response regulator

1.22

−2.64

bpsl0785

Putative lipoprotein

1.19

−1.21

bpss1133

FadH

1.15

−1.30

bpss2053

Cell surface protein

1.12

−2.46

bpsl1043

Putative lipoprotein

1.12

−1.44

bpsl3216

FusA elongation factor EF-2

1.10

−1.10

bpsl1577

TkrA 2-ketogluconate reductase

1.06

−1.30

bpsl1893

Putative type II/IV secretion system ATP-binding protein

1.02

−1.01

σ ^E -dependent but not OSR gene

bpsl0096

SpeG spermidine n(1)-acetyltransferase

NS

−1.29

bpsl0224

Putative GMC oxidoreductase

NS

−1.24

bpsl0327

LysR family regulatory protein

NS

−1.85

bpsl2289

IscS cysteine desulfurase

NS

−1.08

bpss1944

AdhA alcohol dehydrogenase

NS

−1.01

bpss1945

AtpG ATP synthase gamma chain

NS

−1.23

bpss1946

AtpA ATP synthase subunit A

NS

−1.24