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Figure 1 | BMC Genomics

Figure 1

From: Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology

Figure 1

Experimental design. Three healthy foals and three OC-affected foals presenting lesion on the hock were divided in two groups. Healthy (H) and OC-predisposed (OC) cartilage and bone samples were pieced on the stifles. Samples were then subjected (_L) or not (_UL) to a 24-hours experimental loading. Short-read NGS technology (SOLID™, Life Technologies) was performed to define the cartilage and sub-chondral bone miRnomes. Three comparisons were used: between healthy and OC predisposed samples (H vs OC) to test the hypothesis of a constitutive defect, between healthy loaded and unloaded samples (H_L vs H_UL) to evaluate the role of miRNA in the response to biomechanical stress and between healthy and OC-predisposed samples loaded (H_L vs OC_L) to test the hypothesis of a impaired response to mechanical loaded in OC-affected foals.

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BMC Genomics

ISSN: 1471-2164

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