Figure 5

Few highly expressed DEGs are specific to acute infection. (A) To better characterize abundant DEGs, a Venn diagram of the more abundant DEGs in the mouse with a fold change >20 between acute vs uninfected (purple) and chronic vs uninfected (red) time points. Of these more abundant DEGs, 146 were shared between acute and chronic infection (magenta). Only 9 DEGs had a fold change >20 in acute vs uninfected that were also not highly abundant in chronic vs uninfected time points. (B) To analyze the function of the host more abundant DEGs in chronic vs acute time points, GO term enrichment analysis was performed. Many genes differentially expressed in chronic infection are associated with immune regulation and stress response.