Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection

Pittman, Kelly J; Aliota, Matthew T; Knoll, Laura J

doi:10.1186/1471-2164-15-806

BMC Genomics

Table 6 The top 50 mouse DEGs more abundant in chronic vs. acute infection

From: Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection

Gene ID	Description	Gene symbol	Fold change (chronic vs acute)
ENSMUSG00000076652	immunoglobulin heavy variable 7-3	Ighv7-3	672*
ENSMUSG00000076653	immunoglobulin heavy variable 7-2	Ighv7-2	672*
ENSMUSG00000095571	immunoglobulin heavy variable 5-17	Ighv5-17	672*
ENSMUSG00000076564	immunoglobulin kappa chain variable 12-46	Igkv12-46	656*
ENSMUSG00000096422	immunoglobulin kappa variable 12-44	Igkv12-44	656*
ENSMUSG00000076604	immunoglobulin kappa joining 1	Igkj1	353*
ENSMUSG00000076605	immunoglobulin kappa joining 2	Igkj2	353*
ENSMUSG00000076607	immunoglobulin kappa joining 4	Igkj4	353*
ENSMUSG00000076608	immunoglobulin kappa joining 5	Igkj5	353*
ENSMUSG00000076612	immunoglobulin heavy constant gamma 2C	Ighg2c	23*
ENSMUSG00000076617	immunoglobulin heavy constant	Ighm	23*
ENSMUSG00000076618	immunoglobulin heavy joining 4	Ighj4	23*
ENSMUSG00000076619	immunoglobulin heavy joining 3	Ighj3	23*
ENSMUSG00000076621	immunoglobulin heavy joining 1	Ighj1	23*
ENSMUSG00000094028	immunoglobulin heavy diversity 4-1	Ighd4-1	23*
ENSMUSG00000095079	immunoglobulin heavy constant alpha	Igha	23*
ENSMUSG00000095007	immunoglobulin kappa chain variable 12-41	Igkv12-41	356
ENSMUSG00000076609	immunoglobulin kappa chain, constant region	Igkc	353
ENSMUSG00000016283	histocompatibility 2, M region locus 2	H2-M2	111
ENSMUSG00000002992	apolipoprotein C-II	Apoc2	70
ENSMUSG00000074336	apolipoprotein C-IV	Apoc4	70
ENSMUSG00000019987	arginase, liver	Arg1	69
ENSMUSG00000071716	apolipoprotein L 7e	Apol7e	60
ENSMUSG00000058216	cDNA sequence BC021614	BC021614	45
ENSMUSG00000042262	chemokine (C-C motif) receptor 8	Ccr8	44
ENSMUSG00000014453	B lymphoid kinase	Blk	38
ENSMUSG00000050063	kallikrein related-peptidase 6	Klk6	38
ENSMUSG00000082976	predicted gene 15056; similar to beta-defensin 52	Gm15056	38
ENSMUSG00000053977	CD8 antigen, alpha chain	Cd8a	37
ENSMUSG00000030577	CD22 antigen; hypothetical protein LOC100047973	Cd22	36
ENSMUSG00000020017	histidine ammonia lyase	Hal	35
ENSMUSG00000027863	CD2 antigen	Cd2	35
ENSMUSG00000067149	immunoglobulin joining chain	Igj	35
ENSMUSG00000030724	CD19 antigen	Cd19	34
ENSMUSG00000067341	histocompatibility 2, class II antigen E beta2	H2-Eb2	34
ENSMUSG00000068129	cystatin F (leukocystatin)	Cst7	33
ENSMUSG00000079293	C-type lectin domain family 7, member a	Clec7a	32
ENSMUSG00000096594	immunoglobulin kappa variable 8-19	Igkv8-19	32
ENSMUSG00000002033	CD3 antigen, gamma polypeptide	Cd3g	31
ENSMUSG00000050232	chemokine (C-X-C motif) receptor 3	Cxcr3	28
ENSMUSG00000053044	CD8 antigen, beta chain 1	Cd8b1	28
ENSMUSG00000054672	RIKEN cDNA 5830411 N06 gene	5830411N06Rik	28
ENSMUSG00000094738	predicted gene, 26177	Gm26177	28
ENSMUSG00000005947	integrin alpha E, epithelial-associated	Itgae	27
ENSMUSG00000022657	CD96 antigen	Cd96	27
ENSMUSG00000024669	CD5 antigen	Cd5	27
ENSMUSG00000024910	cathepsin W	Ctsw	27
ENSMUSG00000031933	folate receptor 4 (delta)	Folr4	27
ENSMUSG00000026070	interleukin 18 receptor 1	Il18r1	26
ENSMUSG00000035042	chemokine (C-C motif) ligand 5	Ccl5	25

The first column is the ensemble gene ID and the second is the gene name. The third column is the official gene symbol from ensemble.org, and the fourth column is the fold change as average chronic FPKM value was divided by acute. Only genes with a p-value and q-value <0.05 were considered differentially expressed. * in the fold change column indicates the average FPKM value during acute infection was 0, and could not be divided by the average FPKM value in chronic infection.

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ISSN: 1471-2164

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