Figure 3From: The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in AfricaFunctional confirmation of the role of CYP6M7 in pyrethroid resistance. A) Transgenic expression of CYP6M7 in Drosophila. Results of a bioassay with 2% permethrin (A) and 0.15% deltamethrin (B) against the transgenic Act5C-CYP6M7 strain (Experimental) and the progeny from the cross between the UAS-CYP6M7 females and w1118 males (which do not over-express the P450 transgene) (Control). The data shown are the mean ± SEM (n = 6). (C) The proportion of 10 μM insecticide cleared by 0.1 μM P450 with 0.8 μM cyt b5 in the presence of NADPH is indicated by bar height. Error bars represent standard deviation (N = 3).Back to article page