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Table 1 The most up-regulated detoxification genes in Zambia (ZB), Malawi (ML) and Mozambique (MZ) (P < 0.01)

From: The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa

Systematic name

Orthologs in An. gambiae

Fold change (FC)

Description

  

ZB

ML

MZ

 

Afun007663 (CYP6M7)

AGAP008213-PA

37.7

12.5

25.7

Cytochrome p450

CYP6P9a

AGAP002865-PA

15.6

39.4

75.5

Cytochrome p450

CYP6P9b

AGAP002865-PA

11.9

24.0

88.2

Cytochrome p450

Afun008614 (CYP6AA1)

AGAP002862-PA

5.3

5.2

13.2

Cytochrome p450

Afun007346

AGAP007990-PA

2.7

3.1

3.5

Glucosyl glucuronosyl transferases

Afun007469 (CYP9J11)

AGAP012296-PA

4.1

4.8

4.0

Cytochrome p450

CYP6Y2

 

3.9

2.9

4.4

Cytochrome p450

Afun012197 (CYP6Z1)

AGAP003066-PA

2.8

2.9

3.9

Cytochrome p450

Afun009335 (CYP6AG1)

AGAP003343-PA

2.4

2.7

2.6

Cytochrome p450

Afun012194 (CYP6P2)

AGAP002869-PA

2.6

2.7

3.9

Cytochrome p450

Afun007769 (CYP9K1)

AGAP000818-PA

3.6

2.4

2.3

Cytochrome p450

Afun000493

AGAP006225-PA

3.0

2.2

2.6

Aldehyde oxidase

Afun010360

AGAP006222-PA

2.8

2.0

2.1

Glucosyl glucuronosyl transferases

combined_c920 (GSTe2)

 

2.5

3.4

2.8

Glutathione-s-transferase gst

Afun009227

AGAP008141-PA

25.4

66.3

 

Argininosuccinate lyase

Afun010614

AGAP006380-PA

4.0

2.5

 

atp-binding cassette sub-family a member

Afun007482

AGAP002693-PA

3.9

2.3

 

atp-binding cassette sub-family f member 2

Afun011877

AGAP013384-PA

2.5

2.1

 

atp-binding cassette transporter

Afun002473

AGAP000553-PA

6.6

4.5

 

atp-binding-cassette protein

Afun009492

AGAP001722-PA

12.0

5.9

 

Carboxylesterase

CD577459.1

 

2.3

3.0

 

Cuticle protein

CYP6M4

 

5.1

5.3

 

Cytochrome p450

Afun009522

AGAP012292-PA

2.4

4.5

 

Cytochrome p450

Afun003394 (CYP315A1)

AGAP000284-PA

4.5

2.4

 

Cytochrome p450

Afun007127 (CYP4C36)

AGAP009241-PA

2.1

2.4

 

Cytochrome p450

Afun007499 (GSTd1-5)

AGAP004164-PA

2.8

2.9

 

Glutathione transferase

combined_c4173

 

4.6

4.8

 

Glycoprotein 93

combined_c557

 

7.6

11.8

 

Trypsin

CD578169.1

 

3.0

6.0

 

Trypsin

Afun007646

AGAP006225-PA

 

2.0

3.4

Aldehyde oxidase

Afun008347

AGAP009828-PA

 

4.2

2.2

Chymotrypsin 1

Afun013935

AGAP010917-PA

2.2

  

Carboxylesterase

Afun013921

AGAP006709-PA

31.3

  

Chymotrypsin 1

Afun004392

AGAP008213-PA

2.3

  

Cytochrome p450

Afun008909

AGAP002416-PA

2.1

  

Cytochrome p450

Afun012666

AGAP002429-PA

2.1

  

Cytochrome p450

Afun008354 (GSTD3)

AGAP004382-PA

7.8

  

Glutathione transferase

Afun013481(GSTe1)

AGAP009195-PA

2.3

  

Glutathione-s-transferase gst

Afun011899

AGAP012514-PA

2.0

  

Short-chain dehydrogenase

combined_c4812

 

2.7

  

Short-chain dehydrogenase

AGAP007662-RA

AGAP007662-RA

2.4

  

Short-chain dehydrogenase

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BMC Genomics

ISSN: 1471-2164

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