Skip to main content

Table 2 Kinetic parameters for permethrin and deltamethrin metabolism by CYP6M7, CYP6P9a and CYP6P9b

From: The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa

 Genes

Catalytic constant (Kcat) (min-1)

KM(μM)

Catalytic efficiency (Kcat/Km) (min-1 μM-1)

 

Permethrin

Deltamethrin

Permethrin

Deltamethrin

Permethrin

Deltamethrin

CYP6P9a

8.11 ± 1.24

7.469 ± 1.25

18.77 ± 13.76

18.21 ± 8.904

0.432 ± 0.09

0.410 ± 0.141

CYP6P9b

8.37 ± 1.13

7.90 ± 1.10

12.68 ± 10.08

9.9 ± 3.653

0.660 ± 0.112

0.798 ± 0.303

CYP6M7

6.60 ± 0.24

7.035 ± 0.04

13.81 ± 7.075

19.64 ± 10.69

0.478 ± 0.034

0.358 ± 0.004