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Figure 6 | BMC Genomics

Figure 6

From: Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis

Figure 6

Presence of RAX-binding sites in rx3-/-deregulated genes and effect on gene expression. (A) RAX-binding sites in the 5 kb upstream promoter regions of the rx3-/- down-regulated genes. Red bars are consensus binding sites on the positive strand, while blue bars are consensus sites on the negative strand. The enrichment of RAX-binding sites in the promoter regions of deregulated genes was evaluated by 1000 times permutation. The number of random shuffled genes with RAX binding sites (B) and the frequency of RAX-binding motifs in the promoter regions (C) are plotted. *, p < 0.1. (D) Absolute log2 transformed gene expression fold changes between rx3-/- mutants and wild-type phenotype siblings were calculated for genes with diferent number of RAX-binding sites on 5 kb promoter. Significance between different groups of genes was evaluated using one-tail Wilcoxon rank sum test. ***, p < 0.001.

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