Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers

BMC Genomics

Table 1 Summary of genome-wide significant SNPs using a linear mixed model for canine hip dysplasia in UK Labrador retriever

CHR	SNP	Position	Trait	MA	MAF	Beta coef.	P-value	%V_G
1	BICF2P219706	100106009	CrAE left	G	0.019	0.52 ± 0.10	3.35E-07	22.2 ± 17.2
1	BICF2P219706	100106009	CrAE total	G	0.019	0.94 ± 0.18	3.20E-07	13.5 ± 9.90
1	BICF2S2443186	100138261	CrAE left	A	0.019	0.52 ± 0.10	3.34E-07	22.6 ± 17.7
1	BICF2S2443186	100138261	CrAE total	A	0.019	0.94 ± 0.18	3.21E-07	13.8 ± 10.4
1	BICF2P1285984	107719908	CrAE left	G	0.018	0.53 ± 0.10	1.97E-07	33.2 ± 19.5
1	BICF2P1285984	107719908	CrAE total	G	0.018	0.97 ± 0.19	2.20E-07	20.6 ± 11.8
21	BICF2P429643	43337454	NA right	G	0.222	0.40 ± 0.08	3.08E-07	13.1 ± 9.1

The table shows chromosome, significant SNPs, position (in base pairs according to CanFam 2.0), associated trait (total hip score (HS), transformed total hip score (THS), Norberg Angle (NA), Subluxation (SUB) and Cranial Acetabular Edge (CrAE)), minor allele (MA) and its frequency (MAF), Beta coefficient (minor allele substitution effect), P-value for the Beta coefficient from the GWAS analysis and percentage of genetic variance explained by a region of 21 SNPs centred at the significant SNP.

ISSN: 1471-2164