Table 1 GO terms and KEGG pathways enriched with candidate genes for high-altitude adaptation in Tibetan pigs ^a

GO

Gansu

GO:0030011

Maintenance of cell polarity

0.001

ANK1, ANKH, DST

GO:0007270

Neuron-neuron synaptic transmission

0.018

GRIA1, GRIA4, GRM4, GRM5, HTR2A, VDAC1

GO:0030282

Bone mineralization

0.028

ANKH, BMP2, CLEC3B, LTF, TCF7L2

GO:0032663

Regulation of interleukin-2 production

0.041

MALT1, PDE4D

GO:0048566

Embryonic digestive tract development

0.041

GLI3, TCF7L2

GO:0060840

Artery development

0.041

CHD7, FOXS1, GLI3, MYLK2

GO:0018345

Protein palmitoylation

0.042

HHAT, ZDHHC3, ZDHHC7

GO:0016339

Calcium-dependent cell-cell adhesion

0.048

CDH13, CDH17, CDH19

Tibet

GO:0050974

Detection of mechanical stimulus involved in sensory perception

0.029

GRIN2B, ITGA2, PCDH15

GO:0048661

Positive regulation of smooth muscle cell proliferation

0.041

ID2, ITGA2

GO:0060079

Regulation of excitatory postsynaptic membrane potential

0.041

GRIN2B, SEZ6

GO:0010922

Positive regulation of phosphatase activity

0.042

ITGA2, MAGI2, PLEK

GO:0031532

Actin cytoskeleton reorganization

0.049

ABL1, CSF1R, PARVA, PLEK

Sichuan & Yunnan

GO:0097091

Synaptic vesicle clustering

0.010

NRXN1, SYNDIG1

GO:0072337

Modified amino acid transport

0.024

FOLR1, FOLR2, SLC1A4

GO:0072520

Seminiferous tubule development

0.034

ING2, SPINK2

GO:0021575

Hindbrain morphogenesis

0.039

FAIM2, NRXN1

GO:0060079

Regulation of excitatory postsynaptic membrane potential

0.039

GRIK2, NRXN1

GO:1902930

Regulation of alcohol biosynthetic process

0.039

APOB, TWIST1

GO:0017158

Regulation of calcium ion-dependent exocytosis

0.042

B4GALT1, PLCB1, SYT1

GO:0006208

Pyrimidine nucleobase catabolic process

0.042

DPYS, DPYSL3

GO:0007215

Glutamate receptor signaling pathway

0.042

GRIK2, HOMER2, NRXN1, PLCB1

Overall

GO:0010712

Regulation of collagen metabolic process

0.002

CST3, ITGA2, PDGFRB, RGCC

GO:0051567

Histone H3-K9 methylation

0.018

DNMT3B, KDM1A, PRDM5

GO:0050927

Positive regulation of positive chemotaxis

0.033

CDH13, CNTN1, ITGA2

GO:0032465

Regulation of cytokinesis

0.038

PDZD2, TEX14

GO:0019626

Short-chain fatty acid catabolic process

0.043

MUT, PCCA

GO:0050966

Detection of mechanical stimulus involved in sensory perception of pain

0.043

GRIN2B, ITGA2

GO:0002209

Behavioral defense response

0.045

GRIN2B, NR2E1, VDAC1

KEGG

Gansu

KEGG:05217

Basal cell carcinoma

0.031

BMP2, GLI3, TCF7L2

KEGG:04713

Circadian entrainment

0.033

ADCY10, GRIA1, GRIA4, RPS6KA5

KEGG:05033

Nicotine addiction

0.043

GRIA1, GRIA4

KEGG:04520

Adherens junction

0.045

NLK, PTPRB, TCF7L2

Tibet

KEGG:00640

Propanoate metabolism

0.004

ACACB, PCCA, SUCLG2

KEGG:00920

Sulfur metabolism

0.004

IMPAD1, PAPSS2

KEGG:03030

DNA replication

0.024

PRIM2, RPA1

Overall

KEGG:00280

Valine, leucine and isoleucine degradation

0.036

ACADSB, MUT, PCCA

KEGG:04975

Fat digestion and absorption

0.042

APOB, PLA2G12A

KEGG:05014

Amyotrophic lateral sclerosis (ALS)

0.046

DAXX, GRIN2B, MAP2K6