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Table 3 Survival analysis of rrf-3 mutants treated with RNAi against DHHCs and PPTs

From: A systematic analysis of protein palmitoylation in Caenorhabditis elegans

RNAi strain

n

Mean (days)

Median (days)

90% mortality (days)

Maximum (days)

L4440

208

16

16

25

31

dhhc-1

79

16

16

24†

25

dhhc-11

47

12*

10

18

21

dhhc-14

99

19

19†

22†

31

spe-10

79

18

19†

24

29

ppt-1

108

13

12†

23

30

ath-1

47

16

16

25

26

RNAi strain(s)

n

Mean (days)

Median (days)

90% mortality (days)

Maximum (days)

L4440

208

16

17

25

31

dhhc-1 + dhhc-10

50

18

18

24

29

dhhc-2 + dhhc-8

50

13*

13

20†

24

dhhc-3 + dhhc-7

23

19

20

26

28

dhhc-4 + spe-10

34

21*

21†

27

33

dhhc-5 + dhhc-6

27

17

16

25

26

dhhc-9 + dhhc-12

44

18

18

24

26

dhhc-13 + dhhc-14

38

21

21†

24

30

ppt-1 + ath-1

143

14*

14

23

30

  1. Various measures of survival were extracted from lifespan experiments comparing hypersensitive rrf-3 animals treated with feeding RNAi empty vector L4440 control or against DHHC or PPT mutant strains (top). Mixtures of feeding RNAi bacteria were also used to assess simultaneous knockdown of related enzymes (bottom). Statistical tests were applied to values varying from the control using OASIS [73]. *p < 0.01 by the log-rank (Mantel-Cox) test. †p < 0.01 by Fisher’s exact test.r.