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Table 1 Gene Ontology analysis of differentially methylated genes in fetal versus adult livers

From: Genetic and epigenetic regulation of gene expression in fetal and adult human livers

A. Top 10 biological processes associated with hypomethylated genes in adult livers
Term Name P-value Fold enrich.1 Obs. regions2
Steroid metabolic process 2.77E-52 2.03 558
Regulation of lipid metabolic process 4.42E-51 2.06 528
Regulation of generation of precursor metabolites and energy 5.62E-48 3.24 216
Regulation of glycolysis 1.15E-44 5.21 116
Sterol metabolic process 4.28E-44 2.56 288
Positive regulation of lipid metabolic process 3.52E-43 2.48 300
Regulation of cellular carbohydrate catabolic process 3.26E-42 4.22 136
Regulation of lipid transport 3.88E-42 3.54 168
Cholesterol metabolic process 3.71E-40 2.51 271
Regulation of cellular ketone metabolic process 4.25E-39 2.11 381
B. Top 10 biological processes associated with hypomethylated genes in fetal livers
Term Name P-value Fold enrich. 1 Obs. regions 2
Insulin receptor signalling pathway 1.74E-130 77.00 88
Positive regulation of glycogen (starch) synthase activity 1.69E-105 37.19 90
Anterior/posterior pattern specification 1.27E-96 2.26 813
Regulation of gene expression by genetic imprinting 2.36E-92 10.52 143
Regulation of glycogen (starch) synthase activity 3.97E-81 19.01 91
Genetic imprinting 3.54E-69 6.66 147
Response to estrogen stimulus 4.52E-69 2.14 657
Positive regulation of insulin receptor signalling pathway 9.60E-68 11.64 98
Positive regulation of cell cycle 2.83E-61 2.51 421
Luteinizing hormone secretion 4.18E-61 11.24 90
  1. 1Fold enrichment - fold enrichment of number of genomic regions in the test set with the annotation.
  2. 2Observed region hits - actual number of genomic regions in the test set with the annotation.