Table 2 Gene Ontology analysis of differentially expressed genes in fetal versus adult liver
From: Genetic and epigenetic regulation of gene expression in fetal and adult human livers
A. Top 10 biological processes associated with hyperexpressed genes in adult livers | ||
|---|---|---|
Term | P-value | Nr of genes |
Monocarboxylic acid metabolic process | 2.80E-205 | 347 |
Lipid localization | 8.26E-202 | 201 |
Lipid transport | 1.99E-197 | 180 |
Steroid metabolic process | 2.91E-196 | 257 |
Bile acid metabolic process | 1.13E-192 | 40 |
Response to xenobiotic stimulus | 9.88E-184 | 114 |
Cellular response to xenobiotic stimulus | 9.88E-184 | 114 |
Xenobiotic metabolic process | 6.72E-183 | 113 |
Bile acid biosynthetic process | 6.23E-178 | 23 |
Response to glucocorticoid stimulus | 2.61E-173 | 131 |
B. Top 10 biological processes associated with hyperexpressed genes in fetal livers | ||
Term | P-value | Nr of genes |
Negative regulation of organelle organization | 3.93E-162 | 138 |
Regulation of organelle organization | 1.73E-132 | 370 |
Negative regulation of cellular component organization | 3.40E-127 | 265 |
Regulation of chromosome organization | 1.61E-114 | 72 |
Porphyrin-containing compound biosynthetic process | 1.84E-112 | 34 |
Tetrapyrrole biosynthetic process | 1.84E-112 | 34 |
Negative regulation of chromosome organization | 6.05E-108 | 29 |
Chromatin assembly or disassembly | 8.76E-106 | 128 |
Pigment biosynthetic process | 1.73E-103 | 53 |
G1 phase | 6.25E-102 | 36 |