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Table 4 Proportion of explained variation by SNPs and CpG sites associated with the expression of ADME genes

From: Genetic and epigenetic regulation of gene expression in fetal and adult human livers

Gene/Locus Chr SNP CpG site % of variation in expression explained by
SNP only CpG only SNP and CpG site SNP and all CpG sites1
GSTT1 22 rs9612520 cg05380919 50% 75% 78% 84%**
CYP3A5 7 CS015290 cg03133378 55% 7% 57% 57%
GSTM1 1 rs75953876 cg18938907 11% 55% 56% 61%
GPX7 1 rs11810754 cg11953272 48% 16% 49% 52%
UGT1A1 2 rs7592624 cg11811840 22% 41% 45% 47%
SLC22A18 11 rs413781 cg24724917 30% 15% 44% 49%*
FMO4 1 rs2223477 cg14981176 39% 16% 39% 39%
GSTM3 1 rs115636764 cg23645476 21% 20% 35% 46%**
SLC19A1 21 rs7867 cg27210852 22% 10% 30% 30%
GSTO2 10 rs11595547 cg23659134 20% 24% 28% 28%
PON1 7 rs854533 cg07404485 13% 23% 27% 30%
DHRS2 14 rs57350570 cg07125017 23% 4% 26% 26%
GSTA4 6 rs538920 cg22486834 14% 14% 20% 21%
CEBPA 19 rs80241821 cg19035908 17% 6% 20% 20%
MGST3 1 rs10737515 cg16553119 12% 12% 13% 13%
DHRS7 14 rs376391 cg18906360 12% 9% 13% 13%
  1. *F-test p-value < 0.05; **F-test p-value < 0.005.
  2. F-test null hypothesis: model for gene expression with the SNP and CpG site as explanatory variables and model for gene expression with the SNP and all CpG sites1 fit equally well with the differences being due to random chance.
  3. SNP and all CpG sites1 - the CpG sites that have eQTM effects with the expression probe.