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Table 3 HLA discordances between SBT and MIT-NGS HLA genotyping methods

From: High-throughput multiplex HLA genotyping by next-generation sequencing using multi-locus individual tagging

Locus

SBT

MIT-NGS

Classification

B

14:03/35:01:01G

14:02:01/35:08:01 (1)

ambiguous allele combination

DRB1

01:02:01/08:01:05

01:02:01/08:01:03 (1)

nucleotide mismatch

 

08:01:05/08:01:05

08:01:03/08:01:03 (1)

nucleotide mismatch

 

10:01:01/11:01:01G

10:01:01/11:01:02 (1)

nucleotide mismatch

 

03:01:01G/11:01:01G

03:01:01/11:01:02 (1)

nucleotide mismatch

 

11:01:01G/13:01:01G

11:01:02/13:01:01 (1)

nucleotide mismatch

 

11:01:01G/15:03:01G

11:01:02/15:03:01 (1)

nucleotide mismatch

 

13:01:01/14:07:01

13:02:01/14:54:01 (2)

ambiguous allele combination

  1. Discordant alleles are highlighted in bold.
  2. The number of individuals with a given genotype is indicated in parentheses.