Figure 8
From: Transcriptome sequencing of rhizome tissue of Sinopodophyllum hexandrum at two temperatures
Putative podophyllotoxin biosynthetic pathway in S. hexandrum (adapted from[85, 91]). Solid arrow indicates known step whereas broken arrow indicates putative reaction; *shows uncharacterised step. Enzyme abbreviations are as follows: PAL, phenylalanine ammonia lyase; C4H, cinnamate 4-hydroxylase; 4CL, 4-coumarate: CoA ligase; HCT, p-hydroxycinnamoyl-CoA: quinate shikimate p-hydroxycinnamoyl transferase; C3H, p-coumarate 3-hydroxylase; CCoAOMT, caffeoyl-CoA O-methyltransferase; COMT: caffeic acid 3-O-methyltransferase; CCR, cinnamoyl-CoA reductase; CAD, cinnamyl alcohol dehydrogenase; DPO, dirigent protein oxidase; PLR, pinoresinol–lariciresinol reductase; SLD, secoisolariciresinol dehydrogenase; DOP7H, deoxypodophyllotoxin 7-hydroxylase.