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Table 2 Functional categories and number of genes found to be modified by morphine in each category

From: Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression

Functional categories N genes Up‐regulation Down‐regulation
Signal transduction 311 152 ppp1r14ab, camk1γb, grb2, sept9a, itih3, ahnak, hrc, sesn3, megf6, btr22, tmem101, magi1b, vldlr*, hspb1*, plg* 159 LOC566752, a2ml, sh3bp5la, fam115, txndc9, tctex1d2, rcan2, rnf220b, hspb8, slc1a4*, wls*, grik‐l*
Energy metabolism 190 85 itih3, acox1, soat1, cyp17a2, cyp51, cox4.2, alpp, aldocb, pcmt*, plg* 105 aldh8a1, pklr, mpdu1b, mdh1b, phyhd1, hrasls, glb1l, glud1b*
Transcription 109 35 dcps, zbtb16, creb3l3*, junb*, dlx5a*, fos*, dlx4a* 74 sox19b, mettl11a, noc2l, dbx1b, junbb, her4.2, otpb*, sox11b*, sox21b*, hdac6*, dnmt3b*, sox19a*, sox11b*, mir429b
Protein modification and degradation 94 31 ube2d2, hspb1*, plg* 63 pcmt, rad23b, fbxo25, hspb8
Transport 90 43 slc31a1, abca12, apoea, abcb5, ctssb.2*, slc3a2*, abt4*, slc1a3a*, slc7a8* 47 a2ml, bcap31, aqp12, aqp3a, vamp5, slc1a4*, vamp4*, hiat1b*, apoIV*, brp44*, kctd12.2*
Neuronal function 95 36 bnip4, ppp1r14ab, acox1, serinc5, maptb, magi1b, hspb1*, plg*, aplp*, slc1a3a*, creb3l3*, hsp90a.1*, junba*, dlx5a*, fos*, glula 59 pcmt, dao.1, sox19b, a2ml, mettl11a, astn1, noc2l, copb2, dbx1b, junbb, her4.2, slc1a4*, her3*, wls*, grik‐like*, otpb*, cyrano*, sox11b*, sr*, sox21b*, glulb*, glud1b*, dnmt3b*, kctd12.2*, sox11b*, mir429b*
Development 80 36 bnip4, ppp1r14ab, camk1γb, acox1, ahnak, maptb, zbtb16, cyp11a1, magi1b, hspb1*, plg*, dlx5a*, dlx4a* 44 sox19b, a2ml, hspb8, noc2l, copb2, dbx1b, her4.2, her3*, wls*, otpb*, cyrano*, sox11b*, sox21b*, hoxb8a*, dnmt3b*, kctd12.2*, sox11b*
Cell structure and organization 56 27 mybpc2b, maptb, col5a1 29 mylz2, krt1‐19d
Apoptosis 42 19 bnip4, hspb1*, bbc3* 23 hspb8, noc2l, bcap31, casp9*, mir429b*
Cell cycle 31 15 sept9a, sesn3, ccnt1, hsp90a.1*, ccnd1* 16 ccnb3*
Immune response 30 12 ccl‐c11b, cxcl12a, ctssb.2*, plg* 18 crfb6
Amino acid and protein metabolism 28 11 hnmt, eif4a2, eif3hb, eif2c2, slc3a2*, slc7a8* 17 fah, dao.1, aldh18a1, iars, eif4g2b*, sr*, eif4g2a*, eif2s1l*
Replication 25 5 h1fx 20 rad23b, mettl11a, noc2l, h2afx*, dnmt3b*
Ribosomal 17 7 rpf2 10 nob1, fcf1
Response to chemical stimulus 9 3 hspb1*, hsp90a.1* 6 hspb8
Translation 8 2 gcn1l1 6 hbs1l*
Blood Coagulation 8 3 serping1 5 fgg
Stress 7 3 sesn3, hspb1*, hsp90a.1* 4 hspb8
Reproduction 4 3   1  
  1. Some up-regulated genes with FC > 1.0 and down-regulated genes FC < −1.0 are marked with an asterisk (*).