Table 2 Empirical power for tests at nominal level 0.05 based on 1000 replicates
From: Cohen’s h for detection of disease association with rare genetic variants
Fixed gene length (bp) | Mean no of rare SNPs | RD | OR | Cohen’s h | CMC | WSS | VT | |
|---|---|---|---|---|---|---|---|---|
250 | 46.2 | 0.491 | 0.644 | 0.501 | ||||
Unadj. | 0.142 | 0.107 | 0.178 | |||||
BH | 0.042 | 0.037 | 0.051 | |||||
Bonf. | 0.037 | 0.030 | 0.043 | |||||
500 | 96 | 0.878 | 0.931 | 0.882 | ||||
Unadj. | 0.465 | 0.393 | 0.521 | |||||
BH | 0.106 | 0.080 | 0.135 | |||||
Bonf. | 0.087 | 0.064 | 0.113 | |||||
1000 | 187.5 | 0.992 | 0.998 | 0.992 | ||||
Unadj. | 0.584 | 0.509 | 0.652 | |||||
BH | 0.136 | 0.109 | 0.162 | |||||
Bonf. | 0.121 | 0.083 | 0.141 | |||||
2000 | 377.7 | 1 | 1 | 1 | ||||
Unadj. | 0.880 | 0.814 | 0.918 | |||||
BH | 0.254 | 0.194 | 0.306 | |||||
Bonf. | 0.211 | 0.143 | 0.256 | |||||
5000 | 944.3 | 1 | 1 | 1 | ||||
Unadj. | 0.973 | 0.94 | 0.987 | |||||
BH | 0.370 | 0.265 | 0.451 | |||||
Bonf. | 0.305 | 0.191 | 0.388 |