Figure 5
pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice
Hierarchical cluster analysis (HCA) of 54 mouse miRNAs in 6 mouse organs. The female mice received 5 daily doses of 125 mg/kg b.wt/day of BaP by oral gavage. 6 organs were unsupervised clustered with Pearson’s correlation analysis. The results show tissue specific expression patterns (LU-lung, LI-liver, SP-spleen, CO-colon, GS-glandular stomach, FS-forestomach).