Figure 1

Phenotypic manifestation of PIRM syndrome. Most obvious facial feature in PIRM-syndrome is the ptosis. Abnormal large upper eye lid gives a characteristic appearance to affected animals, almost like they were constantly sleepy (A-D). Affected animals also suffered also from hypotonia (A and B) or were smaller than other age matched calves (C and D). In addition owners reported problems with learning and dependency of special care. All animals were euthanized soon after the pictures were taken.