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Figure 3 | BMC Genomics

Figure 3

From: In frame exon skipping in UBE3B is associated with developmental disorders and increased mortality in cattle

Figure 3

The rs475678587 A mutation in UBE3B affects splicing. Genomic structure of bovine UBE3B (A). Bovine UBE3B consists of 32 exons (vertical bars) and its translation starts in exon 7. The position of the HECT-domain was determined according to [18]. Wildtype (wt) and mutant (mt) sequence of exon 23 (B). To improve readability, only part of the genomic sequence is shown. The rs475678587 A mutation affects the very last nucleotide of exon 23 (B) within the highly conserved HECT-domain. Multi-species alignment of the UBE3B protein sequence (C). Alternating colour indicates different exons (22–24). Bold type indicates the initiation of the HECT domain.

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BMC Genomics

ISSN: 1471-2164

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