Figure 1

Overall impact of gliT loss and gliotoxin on A. fumigatus gene expression. A. Differentially regulated genes between A. fumigatus ∆gliT methanol control (∆gliT_MeOH) and A. fumigatus wild-type methanol control (wt-MeOH). The rFPKM value (FPKM (∆gliT_MeOH)/FPKM (wt_MeOH) was plotted for each gene. B. Differentially regulated genes between A. fumigatus wild-type methanol control (wt_MeOH) and A. fumigatus wild-type exposed to gliotoxin (wt_GT). The rFPKM value (FPKM (wt_GT)/FPKM (wt_MeOH) was plotted for each gene. C. Differentially regulated genes between A. fumigatus ∆gliT methanol control (∆gliT_MeOH) and A. fumigatus ∆gliT exposed to gliotoxin (∆gliT_GT). The rFPKM value (FPKM (∆gliT_GT)/FPKM (∆gliT_MeOH) was plotted for each gene. The grey shaded areas highlight the significantly (p <0.05) up-regulated (log₂ fold-change ≥2) and down-regulated (log₂ fold-change ≤2) genes in each set.