RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus

Table 3 Log ₂ (fold change) in siderophore-iron transport gene and siderophore biosynthetic gene expression in A. fumigatus wild-type and ∆ gliT exposed to exogenous gliotoxin

		Wild-type_Glio v Wild-type_MeOH		∆gliT_Glio v ∆ gliT_MeOH
Gene	Gene name	Log₂(fold change)	q value	Log₂(fold change)	q value
Siderophore biosynthesis genes
AFUA_1G17190	sidI	2.393	1.000	0.859	1.000
AFUA_1G04450	sidL	−0.156	0.969	−0.148	0.798
AFUA_1G17200	sidC	1.247	0.105	−0.232	0.694
AFUA_2G07680	sidA	1.066	0.155	2.157	0.0005
AFUA_2G08590	pptA	0.534	0.738	0.854	0.143
AFUA_3G03400	sidF	Present^a	0.005	4.968	0.227
AFUA_3G03410	sidH	3.013	0.172	Present^b	0.0005
AFUA_3G03420	sidD	4.657	1.000	2.815	1.000
AFUA_3G03650	sidG	Present^a	1.000	Present^b	1.000
AFUA_3G03660	estB	1.113	1.000	5.852	0.308
AFUA_5G11260	sreA	−0.740	0.510	−1.152	0.014
Siderophore-iron transport genes
AFUA_1G01430	-	−1.371	0.080	−2.561	0.0005
AFUA_1G14340	-	0.206	0.957	−3.197	0.0005
AFUA_1G16040	-	0.081	0.990	−2.115	0.004
AFUA_2G01270	-	0.011	0.997	−1.605	0.031
AFUA_3G01360	-	0.251	0.969	−2.778	0.045
AFUA_3G02670	-	−1.506	0.054	−2.514	0.0005
AFUA_3G03400	sidF	Present^a	0.005	4.968	0.227
AFUA_3G03440	mirD	2.569	0.005	3.075	0.0005
AFUA_3G13670	-	7.033	0.005	−7.058	0.0005
AFUA_3G13700	-	7.619	0.005	−7.824	0.0005
AFUA_4G03940	fre7	2.803	0.005	−2.765	0.005
AFUA_6G02170	-	−1.026	0.189	−3.820	0.0005
AFUA_6G02820	-	0.290	0.926	−2.396	0.0005
AFUA_6G13750	-	2.256	0.005	−0.998	0.146
AFUA_7G06060	sit1	0.927	0.306	2.785	0.0005
AFUA_8G06210	-	Present^a	1.000	Absent^c	0.0005

^a Switched on in ATCC46645_Glio, ^b switched on in ∆gliT_Glio, ^cGene expression absent in ∆gliT_Glio.

ISSN: 1471-2164