Table 1 Precursor sequences, genome locations and enriched KEGG pathways of significantly up-regulated miRNAs in anestrus
miRNA | Chromosome | Start | End | Strand | miRNA precursor sequence | Enriched KEGG pathways |
|---|---|---|---|---|---|---|
miR-n-783 | chr26 | 38599891 | 38599941 | + | ccaccgggcuccucugaccacgggacuucccagagaagacugcagugggu | MAPK signaling pathway; GnRH signaling pathway; Oxidative phosphorylation |
miR-n-786 | chr21 | 8878698 | 8878742 | + | uugguguaugugcuuggcugagaagccaauggggcgaagcuacc | Androgen and estrogen metabolism; Fatty acid metabolism |
miR-n-784 | chr7 | 84685572 | 84685648 | - | ccacggacuguacaguccuuggggcugcaaagagucggacaggacugagcucuuucaggaaugacaguccccaguc | Basal transcription factors; Fatty acid biosynthesis |
miR-n-787 | chr16 | 496440 | 496499 | + | cugggcuccucugucugaggugacaaugugucaaagucccagcaagagagaguccacag | Notch signaling pathway; Steroid biosynthesis |
miR-n-444 | chr16 | 39273458 | 39273523 | - | caguucccucuuccuugccaguggagaugacagugcucuccaagaagcuggaggggaggacuucc | Notch signaling pathway; Apoptosis |
miR-n-782 | chr2 | 111819172 | 111819244 | + | cguggaucaaagcaucuauggauuucccucgugucuuucccacgaggcuuuccaacgaggcuuucccacagg | Metabolism of xenobiotics by cytochrome P450 |
miR-n-793 | chr4 | 118592936 | 118593008 | - | cguggaucaaagcaucuaugguuuucccucgugucuuucccacgaggcuuucccacgaggcuuucccacagg | Metabolism of xenobiotics by cytochrome P450 |
miR-n-792 | chr16 | 38836730 | 38836775 | - | uccuuuguaaacaucuggaaagccaagcuguaaacucugaggauc | - |
miR-n-790 | chr24 | 5171923 | 5171991 | - | ccauggcuugguucaauacucuuaaguuacuccucaacccauggaagacuaggggacuguuauguguc | Cytokine-cytokine receptor interaction; MAPK signaling pathway |
miR-n-785 | chr3 | 142054999 | 142055066 | - | gcauuaugguuacauuguggcugcugcuacagcucuuguuuccgccaggauggagacuguguuaugg | Basal cell carcinoma; PPAR signaling pathway |
miR-n-788 | chr26 | 232395 | 232460 | + | cagaguugaggcugggagcuccagggcuaagguccugggaccaggcucugggucucugacuuggg | Long-term depression |
miR-n-791 | chr5 | 4904837 | 4904905 | + | ucaggggcaauggccagguggagcugguguggucaguucuggggcuccugggccgugugccccuggac | Insulin signaling pathway; GnRH signaling pathway; MAPK signaling pathway; Notch signaling pathway |
miR-n-795 | chr19 | 52910579 | 52910655 | + | ccagcauugaggggccaguggaauucuggugcaggcucucucccuggcuugccaguggucacuuucuugcuguguc | MAPK signaling pathway |
miR-n-794 | chr2 | 175146052 | 175146125 | + | caaugagggacuggaccaguuggauucugggguaagaaugcucuggguggaaguacuagcuagaacccaggcu | - |