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Table 7 Top 10 under-expressed and over-expressed genes in MDEL vs MDS groups

From: Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

Gene Name

Description

FC

FDR

Under-expressed

   

MHY3

Myosin Heavy Chain Neonatal

-61.4

0

MHY8

Myosin Heavy Chain Embryonic

-32.9

0

GDF15

Growth Differentiation Factor 15

-30.4

0

SNAR-A3

Small nuclear ILF3/NF90-associated RNA A3

-15.8

0

TNNT2

Troponin T2, cardiac

-15.5

0

MYBPH

Myosin binding protein

-14.6

0

DMBT1

Deleted in malignant brain tumors 1

-11.8

0

LMF1

Lipase maturation factor 1

-10

0

COL19A1

Collagen type XIX

-9.9

0

TRIB3

Tribbles homolog 3

-9.6

0

Over-expressed

   

FBP2

Fructose-1,6-bisphosphatase 2

18.4

0

AQP4

Aquaporin 4

17.3

0

C8ORF22

 

14.2

0

ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

10.8

0

KRTAP3-3

Keratin-associated-protein 3

10.6

0

C15ORF27

 

8

0

CALML6

Calmodulin like 6

8

0

DHRS7C

Dehydrogenase/reductase (SDR family) member 7C

7.9

0

MLF1

Myeloid leukemia factor 1

7.1

0

TSPAN8

Tetraspanin-8

7

0

  1. MDEL: mitochondrial DNA deleted group. MDS: mitochondrial DNA depletion syndrome group. FC: fold-change. FDR False Discovery Rate.