Table 9 List of genes differentially expressed (over and under-expressed) relative to control muscle in both MDEL and MDS muscle
Gene Name | Description | FC MDS | FC MDEL |
|---|---|---|---|
ACTN3 | Actinin, alpha 3 | -6.9 | -2.7 |
AQP4 | Aquaporin 4 | -6.2 | +2.8 |
MARCO | Macrophage receptor with collagenous structure | -4 | -4.1 |
TNMD | Tenomodulin | -4 | -4.7 |
C8orf22 | Chromosome 8 open reading frame 22 | -4 | +3.6 |
ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 motif, 8 | - 3.7 | -5.1 |
AGXT2L1 | Alanine-glyoxylate aminotransferase 2-like 1 | -3.5 | -2.5 |
SLITRK4 | SLIT and NTRK-like family, member 4 | -3.3 | -3.4 |
FNDC1 | Fibronectin type III domain containing 1 | -3.2 | -2.5 |
SERPINA5 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -2.8 | -2.4 |
GAS2L2 | Growth arrest-specific 2 like 2 | -2.8 | -2.6 |
MYH1 | Myosin, heavy chain 1, skeletal muscle, adult | -2.7 | +2.8 |
IL32 | Interleukin 32 | -2.6 | -4 |
ITGA10 | Integrin, alpha 10 | -2.5 | -3.3 |
FMOD | Fibromodulin | -2.3 | -4 |
FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.3 | +2.4 |
IL17D | Interleukin 17D | -2.3 | +2.6 |
EIF1AY | Eukaryotic translation initiation factor 1A, Y-linked | -2.2 | -2.5 |
RPS4Y1 | Ribosomal protein S4, Y-linked 1 | -2.1 | -2.7 |
GDF15 | Growth and differentiation factor 15 | +187.9 | +6.2 |
MYH8 | Myosin heavy chain embryonic | +118.7 | +3.6 |
TRIB3 | Tribbles homologue 3 | +47.1 | +5 |
DEFB1 | Defensin beta | +16.6 | +4.5 |
Tmem63c | Transmembrane protein 63C | +16.2 | +2.9 |
SNORD3B-1 | Small nucleolar RNA, C/D box 3B-1 | +6.8 | +3.2 |
SNORD15A | Small nucleolar RNA, C/D box 15A | +6.3 | +3.7 |
SNORA28 | Small nucleolar RNA, H/ACA box 28 | +6.3 | +4.9 |
ATF5 | Activating transcription factor 5 | +6.3 | +2.1 |
HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | +6.2 | +2.7 |
GOS2 | G0/G1 switch regulatory protein | +6.1 | +4.8 |
HBA2 | Hemoglobin, alpha 2 | +5.9 | +4.5 |
XIST | X (inactive)-specific transcript (non-protein coding) | +5.8 | +4.1 |
HBD | Hemoglobin, delta | +5.8 | +5.3 |
C3 | Complement component 3 | +5.6 | +2.1 |
SNORA74A | Small nucleolar RNA, H/ACA box 74A | +5.6 | +2.8 |
HBB | Hemoglobin, beta | +5.5 | +4.9 |
SNORD17 | Small nucleolar RNA, H/ACA box 17 | +5.2 | +2.5 |
PRODH | Proline dehydrogenase (oxidase) 1 | +5.2 | +2.3 |
CD36 | CD36 molecule (thrombospondin receptor) | +4.7 | +2.4 |
CES1 | Carboxylesterase 1 | +4.6 | +2.9 |
SCL26A9 | Solute-linked carrier 26 alpha 9 | +4.4 | +3.6 |
FABP5 | Fatty acid binding protein 5 | +4.4 | +2.3 |
RNU105A | RNA, U105A small nucleolar | +4.3 | +2.2 |
RN7SK | RNA, 7SK small nuclear | +4.3 | +2.7 |
CIDEC | Cell death-inducing DFFA-like effector c | +3.9 | +2.6 |
FABP4 | Fatty acid binding protein 4 | +3.9 | +2.1 |
IGLL5 | Immunoglobulin lambda-like polypeptide 5 | +3.9 | +3 |
ALAS2 | Aminolevulinate, delta-, synthase 2 | +3.3 | +2.6 |
MYL10 | Myosin, light chain 10, regulatory | +3.2 | +4 |
ADH1A | Alcohol dehydrogenase 1A (class I), alpha polypeptide | +3.1 | +3.5 |
SCARNA5 | Small Cajal body-specific RNA 5 | +2.4 | +2.4 |
SNORA81 | Small nucleolar RNA, H/ACA box 81 | +2.3 | +2.3 |
KCNE1L | KCNE1-like | +3 | +2.6 |
RBP4 | Retinol binding protein 4 | +2.9 | +3 |
GZMH | Granzyme H (cathepsin G-like 2, protein h-CCPX) | +2.9 | +2.3 |
HBG1 | Hemoglobin, gamma A | +2.7 | +3.6 |
DPYSL4 | Dihydropyrimidinase-like 4 | +2.6 | +3.1 |
FMO2 | Flavin containing monooxygenase 2 | +2.5 | +2.6 |
C20orf26 | Chromosome 20 open reading frame 26 | +2.5 | +3.5 |
HIST1H4L | Histone cluster 1, H4l | +2.5 | +2.7 |
SCARNA16 | Small Cajal body-specific RNA 16 | +2.5 | +3.9 |
COL21A1 | Collagen, type XXI, alpha 1 | +2.4 | +2.7 |
ANGPTL4 | Angiopoietin-like 4 | +2.4 | -3.5 |
RNU1-5 | RNA, U1 small nuclear 5 | +2.3 | +3.8 |
COL1A1 | Collagen, type I, alpha 1 | +2.1 | -4.2 |
RNU2-2 | RNA, U2 small nuclear 2 | +2 | 1.9 |