Figure 4

Mapping the expression of several gene-sets on RNA-Seq data of MSCs. Scatter plots of log2 (FPKM _sum ) in BM- against PL-MSC samples marking in colors different groups of genes: (A) set of human transcription factors (TF) including 740 genes (purple dots), with135 genes found in the MSC expressed region (hypergeometric p-value > 0.95, not significant); (B) set of 299 stem cell (SC) related genes (orange dots), including 139 found in the MSC expressed region (hypergeometric p-value = 5.96x10^-17, show significant enrichment); (C) set of 158 highly conserved housekeeping (HK) genes (green dots), including 104 found in the MSC expressed region (hypergeometric p-value = 1.31x10^-28, show significant enrichment). (D) Boxplot of the log2(FPKM _sum ) expression distributions of the 3 gene sets (HK, SC, TF) corresponding to PL-MSCs (blue) or BM-MSCs (red).