Figure 4

RNA-binding protein motifs performance comparison. Using 13 CLIP-seq experiments available in the public domain [18], we compared DECOD [13], DREME [11], XXmotif [14] and SeAMotE performances. The ability to identify sequence elements that maximize the separation between positive and reference sets is reported for each motif identified using A) discrimination (Youden’s index) and B) significance (FisherŠs exact test). CMF [12] was excluded from the analysis because it does not allow motif discovery on a nucleic acid specific strand.