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Table 2 Comparison of DREME [11] and SeAMotE

From: SeAMotE: a method for high-throughput motif discovery in nucleic acid sequences

 

SeAMotE

 

DREME

 

Protein

TPR

SPC

PPV

FDR

ACC

TPR

SPC

PPV

FDR

ACC

ELAVL1 (Hafner)

85.3

77.7

79.3

20.7

81.5

83.0

73.2

75.6

24.4

78.1

ELAVL1 (Lebedeva)

80.3

74.9

76.2

23.8

77.6

75.6

74.5

73.3

26.7

75.0

ELAVL1 (Mnase)

86.6

77.8

77.9

22.1

82.2

86.3

71.6

75.2

24.8

79.0

ELAVL1 (Mukharjee)

92.2

82.8

84.3

15.7

87.5

89.5

81.7

83.1

16.9

85.6

FUS

93.2

68.3

74.6

25.4

80.8

92.2

45.3

62.8

37.2

68.8

IGF2BP1-3

92.5

27.5

56.0

44.0

60.0

92.5

27.5

56.0

44.0

60.0

PUM2

91.8

87.5

88.0

12.0

89.6

84.9

92.4

91.8

8.2

88.7

QKI

91.8

87.5

88.0

12.0

89.6

88.4

84.9

85.4

14.6

86.6

SFSR1

86.5

79.6

80.7

19.3

83.0

86.5

79.6

80.7

19.3

83.0

TAF15

95.4

68.4

75.1

24.9

81.9

91.0

54.9

66.9

33.1

73.0

TARDBP (iCLIP)

88.9

89.4

89.3

10.7

89.1

87.9

93.8

93.5

6.5

90.9

TIA1 (iCLIP)

86.7

62.3

70.4

29.6

74.5

86.7

62.3

70.4

29.6

74.5

TIAL1 (iCLIP)

85.5

66.4

72.0

28.0

75.9

84.4

66.2

71.7

28.3

75.3

TOTAL

88.6

73.3

78.0

22.0

80.9

86.8

69.8

75.9

24.1

78.3

  1. Sensitivity (True Positive Rate, TPR), specificity (SPC), precision (Positive Predictive Value, PPV), false discovery rate (FDR) and accuracy (ACC) achieved by the two methods on the CLIP-seq experimental datasets [18].