Table 1 The top 11 loci for Gemcitabine (A) and the top 27 loci for AraC (B) that were associated with drug response-IC50 values

(A) Gemcitabine

rs10513968

−0.382

1.04E-06

DOK6

18

65434121

0.445

Intron

9

rs7719624

−0.370

4.22E-06

TGFBI

5

135405465

0.448

Intron

28

rs2274870

0.362

4.33E-06

NIPSNAP3A

9

106555035

0.371

Coding

7

rs316838

−0.345

1.21E-05

PLD5*

1

240387283

0.093

Intron

12

rs2638094

−0.339

1.72E-05

ZNF215*

11

6938064

0.679

Flanking_3UTR

5

rs2290344

0.339

1.75E-05

PIGB

15

53407088

0.253

Coding

9

rs3129890

0.332

2.67E-05

HLA-DRA*

6

32522251

0.340

Flanking_3UTR

23

rs2928445

−0.331

2.76E-05

IPMK

10

58816782

0.267

Flanking_3UTR

23

rs4392391

−0.318

5.78E-05

C3orf23

3

44247970

0.419

Downstream

15

rs12522395

0.318

6.58E-05

MASS1*

5

90246274

0.215

Intron

4

rs13171512

−0.313

7.857E-05

PIK3R1

5

68000787

0.462

Flanking_3UTR

4

(B) AraC

rs10495285

0.393

4.13E-07

KIAA0133 (URB2)

1

227871618

0.171

Downstream

2

rs1450679

0.389

5.20E-07

SMC2L1

9

106066633

0.098

Flanking_3UTR

8

rs6128386

0.375

1.38E-06

LOC149773

20

56626955

0.466

Upstream

4

rs2172820

−0.373

1.63E-06

TUSC3

8

15370039

0.256

Flanking_5UTR

13

rs2857891

−0.372

1.75E-06

ZNF215*

11

6919533

0.101

Intron

6

rs9512755

−0.361

3.67E-06

LNX2

13

27056229

0.055

Flanking_5UTR

4

rs888468

−0.356

5.08E-06

FGF6

12

4403640

0.184

Flanking_3UTR

5

rs2653165

−0.347

9.28E-06

PLD5*

1

240432905

0.207

Intron

7

rs11215416

−0.346

9.57E-06

IGSF4

11

114582537

0.147

Intron

7

rs10060641

0.335

1.90E-05

MASS1*

5

90249006

0.216

Intron

7

rs5989586

0.336

1.94E-05

HDHD1A

23

6757306

0.457

Flanking_3UTR

8

rs216465

−0.330

2.76E-05

GOSR1

17

25880801

0.494

Flanking_3UTR

12

rs856548

−0.326

3.29E-05

TNS3

7

46730993

0.296

Flanking_3UTR

8

rs6689258

0.325

3.40E-05

GPR137B

1

234362702

0.267

Flanking_5UTR

2

rs3794794

−0.325

3.61E-05

CPD

17

25744867

0.477

Intron

10

rs7192

0.322

4.10E-05

HLA-DRA*

6

32519624

0.371

Coding

11

rs4572738

0.322

4.45E-05

CAST1

3

55799452

0.321

Intron

8

rs1433446

0.319

5.05E-05

TMEM83

15

85351874

0.109

Flanking_5UTR

5

rs300962

0.320

5.47E-05

LOC51334

5

119909842

0.269

Intron

15

rs6441911

0.315

6.20E-05

RIS1

3

45322523

0.055

Flanking_5UTR

6

rs1159388

0.314

6.61E-05

DCAMKL1

13

35544706

0.172

Intron

11

rs718979

0.313

6.82E-05

UBE3A

15

23325370

0.394

Flanking_5UTR

6

rs1955412

0.309

8.74E-05

FLRT2

14

85082547

0.21

Intron

11