Table 2 List of membrane proteins and N-glycosylation sites associated with microglial physiology

Microglia marker

CD11b

Itgam

Integrin alpha-

58 N, 391 N, 696 N, 734 N, 907 N, 941 N, 1022 N, 1045 N

13.2% (B1)

CD18

Itgb2

Integrin beta-2

51 N, 502 N, 626 N, 644 N

29.8% (B2)

CD11c

Itgax

Integrin alpha-X

393 N*

Glycol-only

Ptprc

Receptor-type tyrosine-protein phosphatase C

210 N*, 215 N*, 247 N*, 268 N*, 279 N*, 290 N*, 304 N*, 311 N*, 322 N*, 347 N*, 384 N*, 427 N*, 446 N*, 489 N*, 1237 N*

27.9% (B2)

CD68

Cd68

Macrosialin

129 N*, 134 N*, 169 N*, 178 N, 260 N

16.1% (B2)

F4/80 antigen

Emr1

EGF-like module-containing mucin-like hormone receptor-like 1

405 N*, 413 N*, 417 N*, 498 N

21.3% (B2)

Iba1

Aif1

Allograft inflammatory factor 1

-

8.2% (B2)

Ion channel

Calcium channel

TRPs

Trpm7

Transient receptor potential cation channel subfamily M member 7

-

1.7% (B1)

Trpc2

Short transient receptor potential channel 2

-

0.8% (B1)

Trpc4

Short transient receptor potential channel 4

-

0.8%(B1)

Trpv2

Transient receptor potential cation channel subfamily V member 2

567 N*

33.1%(B1)

Potassium channel

Inward rectifier potassium channels

Kcnj2

Inward rectifier K(+) channel Kir2.1

-

3.3%(B1)

BK channels

Kcnma1

Calcium-activated potassium channel subunit alpha-1

-

1.6%(B2)

Kcnu1

Calcium-activated potassium channel subunit alpha-3

339 N*

Glyco-only

Kcnmb3

Calcium-activated potassium channel subunit beta-3

-

4.6%(B2)

Kcnab2

Voltage-gated potassium channel subunit beta-2

-

8.6%(B2)

anion channels

CLIC-1 chloride channels

Clic1

Chloride intracellular channel protein 1

-

60.6%(B2)

other channels

Proton channels

Hvcn1

Hydrogen voltage-gated channel 1

-

13.4%(B1)

Neuro-Trans-mitter Receptor

Purino ceptors

P2X4

P2rx4

P2X purinoceptor 4

75 N, 131 N, 153 N*, 184 N, 208 N

21.6%(B2)

P2X7

P2rx7

P2X purinoceptor 7

74 N, 187 N, 202 N, 213 N

12.8%(B1)

P2Y6, P2Y10

P2ry6

P2Y purinoceptor 6

-

3.7%(B1)

A630033H20Rik

Novel protein similar to purinergic receptor P2Y G-protein coupled 10 (P2ry10)

-

3.7%(B1)

Glutamate receptor

AMPA receptors

Gria2

AMPA-selective glutamate receptor 2

-

1.7%(B2)

Metabotropic glutamate receptors

Grm1

Isoform 1 of Metabotropic glutamate receptor 1

-

2%(B1)

GABA receptors

Gabra5

Gamma-aminobutyric acid receptor subunit alpha-5

-

1.7%(B1)

Neuro-hormones and neuro-modu-lators receptor

Glucocorticoid receptors

Glucocorticoid receptor

Nr3c1

Glucocorticoid receptor

-

4.2%(B1)

Opioid receptors

Sigmar1

Sigma 1-type opioid receptor

-

43.5%(B2)

Ogfr

Opioid growth factor receptor

-

17.1%(B2)

Cytokine receptors

TNF-alpha receptors

Tnfr2

TNF-alpha receptor 2

-

9.5%(B1)

Tnfrsf1b

TNF receptor superfamily member 1B

-

9.5%(B1)

Tnfrsf26

TNF receptor superfamily member 26

136 N*

14.2%(B1)

Interleukin receptors

Il2rg

Interleukin 2 receptor, gamma chain

96 N, 159 N*, 164 N*, 306 N*

5.1%(B1)

Il10rb

Interleukin-10 receptor subunit 2

51 N*

11.4%(B1)

Il13ra1

Interleukin-13 receptor subunit alpha-1

262 N

Glyco-only

Il6st

Interleukin-6 receptor subunit beta

43 N

Glyco-only

Il10ra

Interleukin-10 receptor subunit alpha

113 N*

Glyco-only

Il4ra

Isoform 1 of Interleukin-4 receptor subunit alpha

163 N

Glyco-only

Csf2rb

Cytokine receptor common subunit beta

141 N*

2.7%(B1)

Other receptor system

Notch receptors

Notch2

neurogenic locus notch homolog protein 2

-

3.3%(B1)

Complement receptors

C5ar1

Complement component 5a receptor 1

-

9.4%(B1)

Macrophase colony-stimulating factor receptors

Csf1r

Macrophage colony-stimulating factor 1 receptor

-

16.6%(B1)

Csf2ra

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

132 N*, 165 N, 269 N*

Glyco-only

Formyl peptide receptors

Fpr1

fMet-Leu-Phe receptor

-

9.3%(B2)

CD200 receptors

Cd200r1

CD200 cell surface glycoprotein receptor

93 N, 192 N*

5.5%(B1)

Cd200r4

CD200 cell surface glycoprotein receptor-like 4

-

12.6%(B1)