Figure 5

Relationship between RNAPII occupancy and chromatin modification. (A-C) Distribution of correlation between the binding of the three forms of RNAPII and 13 different histone mark occupancy profiles for ChIP-enriched probes showing an oscillating profile with p <0.05 and ≥1.5 fold change across the IDC. Correlation distributions were plotted as histograms for each histone modification, with bins of PCC ranging from −1 to +1 plotted against the fraction of probes falling into each bin (the number of probes falling into each bin over the total number of probes assessed) for random vs. observed distributions. A Kolmogorov-Smirnov test was applied to compare observed and random correlations, and the statistical significance (p) of the observed distribution can be seen at the bottom of each graph. Modified degree of skewness (S) of the PCC distribution is given on the bottom right of each graph (see Methods). See also Additional files 5, 6 and 7: Figures S4, S5 and S6.