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Figure 5 | BMC Genomics

Figure 5

From: A network biology workflow to study transcriptomics data of the diabetic liver

Figure 5

Significant amount of antidiabetic drugs targeting gene products in the network. The network has been extended with drug-target interactions from DrugBank 4 using CyTargetLinker. Nodes present in only one pathway and not targeted by any drugs have been grouped in pathway nodes (yellow rounded rectangles). Drugs targeting genes in the network are indicated as blue rectangles, drugs associated with diabetes are colored in red, micronutrients/dietary supplements in green, drugs related to immune response in orange and anticholesteremic agents in purple. Diabetes related drugs target 7 gene products in the network: INSR (8 drugs), PPARG (5 drugs), RB1 (2 drugs), ABCA1 (1 drug), CPT1A (1 drug), PRKAA1 (1 drug), PRKAB1 (1 drug).

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