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Table 2 Functional areas (GO terms of the category “biological process”), topically sorted (left column), of the genes interacting with miRNAs, i.e., for which a gene versus miRNA interaction has been experimentally shown, sorted for the number of genes included

From: What do all the (human) micro-RNAs do?

 

Functional area

GO term ID

Number of genes

   

Fraction [%]

Observed

Expected

[− log10 p-val]

BR

Biological regulation

GO:0065007

38.9

1149

817

54.3

Metabolism

Primary metabolic process

GO:0044238

34.2

1009

805

20

Cellular macromolecule metabolic process

GO:0044260

29.2

864

615

34.4

Nitrogen compound metabolic process

GO:0006807

23.2

685

478

27.6

Cellular biosynthetic process

GO:0044249

21

620

428

25.5

Information transmission

Signaling

GO:0023052

22.7

671

489

21

Response to stimulus

GO:0050896

17

501

381

10.4

Cell communication

GO:0007154

10.8

319

207

15.2

Development

Developmental process

GO:0032502

17.3

512

352

20.5

Cellular component organization

GO:0016043

15.5

459

341

10.9

Multicellular organismal development

GO:0007275

15.2

448

305

18

Cell proliferation

GO:0008283

8.9

262

152

19.2

Cellular component movement

GO:0006928

4.9

142

77

11.8

Biological adhesion

GO:0022610

4.2

123

77

5.4

GE

Gene expression

GO:0010467

18.8

554

380

22.9

TH

Cell death

GO:0008219

8.2

243

138

18.8

 

Cell cycle

GO:0007049

6.1

180

115

8.1

  1. BR: biological regulation, GE: gene expression, TH: tissue homeostasis.
  2. Significant and remarkable gene ontology (GO) terms (for definition see the AmiGO search tool for GO [23]) resulted from over-representation analysis (ORA) of the 2945 genes with experimentally shown or computationally predicted miRNA interaction that were annotated to the GO category “biological process”.