Distribution of shared and orphan NRPS/PKS gene clusters detected in Cyanobacteria. The species tree was generated by a concatenation of twenty-nine conserved proteins using a Maximum Likelihood method. The clades a to h of the phylogenetic tree are supported by a bootstrap of ≥70%. The species tree is connected to the distribution pattern by lines. The lines are plain for complete genome and dashed for unfinished genomes and indicate the habitat of the strains: blue for fresh water, green for marine and black for other. On the distribution pattern, the cluster families involved in the biosynthesis of known product are first indicated in the grey shadowed area from CF-1 to CF-19, followed by the shared ones and encoding potentially unknown product from CF-20 to CF-61 with a white background while the last column indicates the number of orphans. The PKS clusters are indicated in blue, hybrid in red and NRPS in green. Each cluster is indicated by a dot, except for two gene clusters present in double copy in the genome of PCC 9339 that are indicated by a larger dot. The colored clusters on the same vertical line are related to each other and define a family of clusters. Details on the species tree and on the clusters and cluster families are available on Additional file 2: Figure S1 and Additional file 1: Table S1, S2 and S3.