Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria

BMC Genomics

Table 1 NRPS/PKS gene clusters and cluster families

Types of clusters	No. of clusters	No. of clusters of		Orphan	No. of CF
Types of clusters	No. of clusters	Known product (CF)	Unknown product (CF)	Orphan	No. of CF
PKS	162	61 (6)	48 (13)	53	72
Hybrid	100	13 (7)	36 (14)	51	72
NRPS	190	17 (6)	52 (15)	121	142
Total	452	91 (19)	136 (42)	225	286

Gene clusters encoding NRPS, PKS and hybrid NRPS/PKS were found in 89 out of 126 cyanobacterial genomes (Additional file 1: Table S1). Several gene clusters were shared among Cyanobacteria, forming cluster families (CFs). Some CFs correspond to biosynthetic pathways of known products, whereas others without associated products were recovered using BLASTP and a transitive link criterion to build families. The other half of the gene clusters were orphans, each forming a putative family by its own.

ISSN: 1471-2164