Diagram of extracting DNA methylation pattern and calculation of entropy. Step 1. Mapping paired-end DNA methylation reads to Human reference; Step 2. Extracting DNA methylation calls; Step 3. Obtaining 4 contiguous CpG dinucleotides involved segments; Step 4. Calculating DNA methylation entropy for each segment. Filled and open circles represent methylated and unmethylated CpG dinucleotides, respectively.