Distribution of DNA methylation level and entropy for three methylomes. The distribution was calculated based on the 754,372 common segments of all three methylomes. (A) DNA methylation level. (B) DNA methylation entropy. The DNA methylation level was plotted against the DNA methylation entropy for all three cell-types: ADS (C), ADS-adipose (D), and ADS-iPSCs (E). The distribution of the median of the methylation entropies for simulated segments with 4 CpG sites was plotted (F).