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Table 5 Vienna7 pupae vs. wild Hawaiian wild-type pupae differentially regulated genes GO term enrichment

From: A genomic perspective to assessing quality of mass-reared SIT flies used in Mediterranean fruit fly (Ceratitis capitata) eradication in California

Term Annotated Significant Expected Fisher exact test p-value
Up-regulated genes
GO:0006412 Translation 103 45 20.64 2.90E-08
GO:0022900 Electron transport chain 48 24 9.62 3.00E-06
GO:0019079 Viral genome replication 13 10 2.61 1.60E-05
GO:0009409 Response to cold 8 7 1.6 8.40E-05
GO:0019058 Viral infectious cycle 18 11 3.61 0.00016
GO:0006091 Generation of precursor metabolites 117 40 23.45 0.0002
GO:0009631 Cold acclimation 5 5 1 0.00032
GO:0022904 Respiratory electron transport chain 12 8 2.41 0.00058
GO:0006626 Protein targeting to mitochondrion 10 7 2 0.00086
GO:0070585 Protein localization to mitochondrion 10 7 2 0.00086
GO:0072655 Establishment of protein localization 10 7 2 0.00086
GO:0065004 Protein-DNA complex assembly 27 13 5.41 0.00093
GO:0042773 ATP synthesis coupled electron transport 8 6 1.6 0.00123
GO:0042775 Mitochondrial ATP coupled electron transport 8 6 1.6 0.00123
GO:0044237 Vellular metabolic process 2258 492 452.56 0.00136
GO:0016032 Viral reproduction 39 16 7.82 0.00211
GO:0044764 Multi-organism cellular process 39 16 7.82 0.00211
GO:0008152 Metabolic process 2745 586 550.16 0.00217
GO:0016125 Sterol metabolic process 36 15 7.22 0.0024
GO:0007017 Microtubule-based process 186 53 37.28 0.00298
GO:0006119 Oxidative phosphorylation 9 6 1.8 0.00307
GO:0006767 Water-soluble vitamin metabolic process 9 6 1.8 0.00307
GO:0034660 NcRNA metabolic process 74 25 14.83 0.00365
GO:0006839 Mitochondrial transport 21 10 4.21 0.00405
GO:0006457 Protein folding 52 19 10.42 0.00407
GO:0042254 Ribosome biogenesis 60 21 12.03 0.00467
GO:0042982 Amyloid precursor protein metabolism 7 5 1.4 0.00468
GO:0045940 Positive regulation of steroid metabolism 7 5 1.4 0.00468
GO:0031047 Gene silencing by RNA 28 12 5.61 0.00491
GO:0015931 Nucleobase-containing compound transport 53 19 10.62 0.00518
GO:0009617 Response to bacterium 72 24 14.43 0.00528
GO:0044267 Cellular protein metabolic process 609 146 122.06 0.00579
GO:0000226 Microtubule cytoskeleton organization 137 40 27.46 0.00594
GO:0022415 Viral reproductive process 32 13 6.41 0.00598
GO:0007379 Segment specification 22 10 4.41 0.00611
GO:0008202 Steroid metabolic process 54 19 10.82 0.00653
GO:0001666 Response to hypoxia 43 16 8.62 0.00663
GO:0006379 mRNA cleavage 5 4 1 0.00674
GO:0034433 Steroid esterification 5 4 1 0.00674
GO:0034434 Sterol esterification 5 4 1 0.00674
Down-regulated genes
GO:0065007 Biological regulation 1938 577 429.5 5.50E-28
GO:0050794 Regulation of cellular process 1625 503 360.13 4.80E-27
GO:0007154 Cell communication 996 346 220.73 4.00E-26
GO:0023052 Signaling 980 341 217.19 8.30E-26
GO:0044700 Single organism signaling 980 341 217.19 8.30E-26
GO:0050789 Regulation of biological process 1780 533 394.48 4.40E-25
GO:0003008 System process 462 185 102.39 2.30E-20
GO:0048646 Anatomical structure formation 662 240 146.71 9.10E-20
GO:0044699 Single-organism process 2913 755 645.58 1.90E-19
GO:0044763 Single-organism cellular process 2412 653 534.55 2.50E-19
GO:0009653 Anatomical structure morphogenesis 761 265 168.65 3.80E-19
GO:0050877 Neurological system process 385 158 85.32 1.50E-18
GO:0048468 Cell development 610 222 135.19 2.20E-18
GO:0007165 Signal transduction 804 274 178.18 2.40E-18
GO:0044707 Single-multicellular organism process 1699 491 376.53 7.30E-18
GO:0044767 Single-organism developmental process 1185 369 262.62 7.60E-18
GO:0030182 Neuron differentiation 331 140 73.36 8.60E-18
GO:0032501 Multicellular organismal process 1737 497 384.95 4.10E-17
GO:0048513 Organ development 697 242 154.47 4.10E-17
GO:0010646 Regulation of cell communication 412 161 91.31 1.90E-16
GO:0035556 Intracellular signal transduction 359 145 79.56 2.90E-16
GO:0048731 System development 1025 324 227.16 2.90E-16
GO:0023051 Regulation of signaling 417 162 92.42 2.90E-16
GO:0048699 Generation of neurons 356 144 78.9 3.20E-16
GO:0007267 Cell-cell signaling 264 115 58.51 8.30E-16
GO:0007268 Synaptic transmission 181 88 40.11 9.20E-16
GO:0048856 Anatomical structure development 1301 389 288.33 1.60E-15
GO:0009887 Organ morphogenesis 316 130 70.03 2.30E-15
GO:0032989 Cellular component morphogenesis 362 143 80.23 4.50E-15
GO:0016043 Cellular component organization 1160 353 257.08 4.90E-15
GO:0050793 Regulation of developmental process 339 135 75.13 1.40E-14
GO:0007275 Multicellular organismal development 1356 398 300.52 1.90E-14
GO:0030154 Cell differentiation 927 292 205.44 3.70E-14
GO:0035637 Multicellular organismal signaling 206 93 45.65 4.60E-14
GO:0019226 Transmission of nerve impulse 203 92 44.99 4.70E-14
GO:0000904 Cell morphogenesis involved in different… 249 106 55.18 8.40E-14
GO:0009966 Regulation of signal transduction 363 140 80.45 9.10E-14
GO:0007399 Nervous system development 617 210 136.74 1.20E-13
GO:0048666 Neuron development 294 119 65.16 1.70E-13
GO:0000902 Cell morphogenesis 315 125 69.81 2.10E-13
GO:0048869 Cellular developmental process 964 298 213.64 3.00E-13