Table 6 Vienna7 adults vs. wild Hawaiian wild-type adults differentially regulated genes GO term enrichment

Up-regulated genes

GO:0044260

Cellular macromolecule metabolic process

1441

270

190.73

7.90E-14

GO:0006396

RNA processing

166

56

21.97

3.50E-12

GO:0044237

Cellular metabolic process

2258

372

298.87

1.40E-11

GO:0022613

Ribonucleoprotein complex biogenesis

73

31

9.66

4.60E-10

GO:0043170

Macromolecule metabolic process

1839

311

243.41

5.20E-10

GO:0008152

Metabolic process

2745

425

363.33

1.40E-09

GO:0034660

ncRNA metabolic process

74

30

9.79

3.40E-09

GO:0071704

Organic substance metabolic process

2587

403

342.41

6.90E-09

GO:0042254

Ribosome biogenesis

60

26

7.94

7.30E-09

GO:0006364

rRNA processing

35

19

4.63

8.00E-09

GO:0034470

ncRNA processing

53

24

7.02

9.60E-09

GO:0016072

rRNA metabolic process

36

19

4.76

1.50E-08

GO:0044238

Primary metabolic process

2432

382

321.9

1.70E-08

GO:0090304

Nucleic acid metabolic process

948

175

125.48

1.20E-07

GO:0006457

Protein folding

52

22

6.88

1.80E-07

GO:0034641

Cellular nitrogen compound metabolism

1291

221

170.88

8.10E-07

GO:0046483

Heterocycle metabolic process

1212

209

160.42

1.20E-06

GO:0006725

Cellular aromatic compound metabolism

1231

211

162.93

1.60E-06

GO:0006139

Nucleobase-containing compound metabolism

1166

201

154.33

2.30E-06

GO:0044267

Cellular protein metabolic process

609

118

80.61

2.50E-06

GO:1901360

Organic cyclic compound metabolism

1289

218

170.61

2.90E-06

GO:0006974

Response to DNA damage stimulus

136

38

18

3.00E-06

GO:0000075

Cell cycle checkpoint

44

18

5.82

4.30E-06

GO:0031570

DNA integrity checkpoint

33

15

4.37

5.80E-06

GO:0030163

Protein catabolic process

110

32

14.56

7.30E-06

GO:0044265

Cellular macromolecule catabolic process

143

38

18.93

1.10E-05

GO:0071156

Regulation of cell cycle arrest

47

18

6.22

1.30E-05

GO:0000077

DNA damage checkpoint

28

13

3.71

1.90E-05

GO:0009451

RNA modification

18

10

2.38

2.50E-05

GO:0007050

Cell cycle arrest

58

20

7.68

2.70E-05

GO:0016071

mRNA metabolic process

122

33

16.15

2.80E-05

GO:0051603

Proteolysis involved in cellular protein…

88

26

11.65

4.00E-05

GO:0006807

Nitrogen compound metabolic process

1455

234

192.58

5.70E-05

GO:0006270

DNA replication initiation

10

7

1.32

5.70E-05

GO:0044257

Cellular protein catabolic process

90

26

11.91

6.10E-05

GO:0019079

Viral genome replication

13

8

1.72

6.30E-05

GO:0007093

Mitotic cell cycle checkpoint

31

13

4.1

7.00E-05

GO:0022403

Cell cycle phase

246

54

32.56

7.10E-05

GO:0009057

Macromolecule catabolic process

201

46

26.6

8.70E-05

GO:0010389

Regulation of G2/M transition of mitotic…

28

12

3.71

0.0001

GO:0051329

Interphase of mitotic cell cycle

73

22

9.66

0.00011

Down-regulated genes

GO:0071482

Cellular response to light stimulus

14

11

1.59

9.80E-09

GO:0007603

Phototransduction, visible light

10

9

1.14

2.70E-08

GO:0016056

Rhodopsin mediated signaling pathway

10

9

1.14

2.70E-08

GO:0048646

Anatomical structure formation involved…

662

118

75.31

4.80E-08

GO:0007600

Sensory perception

142

39

16.15

6.40E-08

GO:0009583

Detection of light stimulus

29

15

3.3

9.60E-08

GO:0009584

Detection of visible light

19

12

2.16

9.80E-08

GO:0042692

Muscle cell differentiation

123

35

13.99

1.20E-07

GO:0001539

Ciliary or flagellar motility

11

9

1.25

1.30E-07

GO:0051239

Regulation of multicellular organismal processes

413

81

46.98

1.70E-07

GO:0003008

System process

462

88

52.55

1.90E-07

GO:0009581

Detection of external stimulus

38

17

4.32

2.00E-07

GO:0016059

Deactivation of rhodopsin mediated signa…

9

8

1.02

2.20E-07

GO:0022400

Regulation of rhodopsin mediated signali…

9

8

1.02

2.20E-07

GO:0009582

Detection of abiotic stimulus

39

17

4.44

3.20E-07

GO:0055002

Striated muscle cell development

86

27

9.78

4.00E-07

GO:0007602

Phototransduction

21

12

2.39

4.60E-07

GO:0055001

Muscle cell development

92

28

10.47

5.00E-07

GO:0030239

Myofibril assembly

36

16

4.1

5.10E-07

GO:0061061

Muscle structure development

174

42

19.79

9.80E-07

GO:0050953

Sensory perception of light stimulus

70

23

7.96

1.20E-06

GO:0051606

Setection of stimulus

48

18

5.46

2.10E-06

GO:0071478

Cellular response to radiation

20

11

2.28

2.40E-06

GO:0007018

Microtubule-based movement

53

19

6.03

2.40E-06

GO:0007601

Visual perception

68

22

7.74

2.80E-06

GO:0050877

Neurological system process

385

73

43.8

3.00E-06

GO:0048468

Cell development

610

104

69.39

3.70E-06

GO:0009653

Anatomical structure morphogenesis

761

124

86.57

3.80E-06

GO:0044707

Single-multicellular organism process

1699

239

193.27

4.80E-06

GO:0051146

Striated muscle cell differentiation

108

29

12.29

5.40E-06

GO:0030182

Neuron differentiation

331

64

37.65

6.90E-06

GO:0032501

Multicellular organismal process

1737

242

197.59

9.10E-06

GO:0031032

Actomyosin structure organization

44

16

5.01

1.20E-05

GO:0040011

Locomotion

380

70

43.23

1.40E-05

GO:0009416

Response to light stimulus

55

18

6.26

1.90E-05

GO:0032101

Regulation of response to external stimuli

55

18

6.26

1.90E-05

GO:0071214

Cellular response to abiotic stimulus

28

12

3.19

2.20E-05

GO:0007606

Sensory perception of chemical stimulus

56

18

6.37

2.50E-05

GO:0032989

Cellular component morphogenesis

362

66

41.18

3.70E-05

GO:0048699

generation of neurons

356

65

40.5

4.10E-05

GO:2000026

Regulation of multicellular organismal development

228

46

25.94

5.10E-05